B
Bernhard Widner
Researcher at University of Innsbruck
Publications - 83
Citations - 4912
Bernhard Widner is an academic researcher from University of Innsbruck. The author has contributed to research in topics: Neopterin & Kynurenine. The author has an hindex of 34, co-authored 83 publications receiving 4627 citations.
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Journal ArticleDOI
Neopterin as a Marker for Immune System Activation
TL;DR: Neopterin production provides prognostic information in patients with malignant tumor diseases and in HIV-infected individuals, high levels being associated with poorer survival expectations and the extent of oxidative stress can be estimated by neopterin measurements.
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Simultaneous measurement of serum tryptophan and kynurenine by HPLC.
TL;DR: A new HPLC method is described to determine the amounts of kynurenine and tryptophan in serum simultaneously with use of an external albumin-based calibrator and an internal calibrator, enabling indirect examination of endogenous interferon-γ formation.
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Tryptophan degradation and immune activation in Alzheimer's disease
TL;DR: Tryptophan degradation due to immune activation may exert impact on the pathogenesis of AD and increased Kyn/Trp was associated with reduced cognitive performance.
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Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer
TL;DR: A role for interferon-γ-mediated serum tryptophan decrease in cancer-induced quality of life deterioration is supported in patients with colorectal liver metastases.
Journal ArticleDOI
Neopterin production, tryptophan degradation, and mental depression--what is the link?
Bernhard Widner,Andreas Laich,Barbara Sperner-Unterweger,Maximilian Ledochowski,Dietmar Fuchs +4 more
TL;DR: Enhanced neopterin concentrations together with increased degradation of tryptophan and low serum levels of tryPTophan correlate with neuropsychiatric abnormalities like cognitive decline and depressive symptoms especially in long-lasting and chronic diseases.