B
Bharath K. Mani
Researcher at University of Texas Southwestern Medical Center
Publications - 38
Citations - 1143
Bharath K. Mani is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Ghrelin & Growth hormone secretagogue receptor. The author has an hindex of 17, co-authored 36 publications receiving 836 citations. Previous affiliations of Bharath K. Mani include KTU Faculty of Medicine & Loyola University Chicago.
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Journal ArticleDOI
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse
Bharath K. Mani,Angela K. Walker,Eduardo Javier López Soto,Jesica Raingo,Charlotte E. Lee,Mario Perello,Zane B. Andrews,Jeffrey M. Zigman +7 more
TL;DR: The GHSR‐eGFP reporter mouse model may be a useful tool for studying GHSGHSR function, particularly within the brainstem and hippocampus; however, it underrepresents G HSR expression in nuclei within the hypothalamus and midbrain.
Journal ArticleDOI
LEAP2 changes with body mass and food intake in humans and mice
Bharath K. Mani,Nancy Puzziferri,Nancy Puzziferri,Zhenyan He,Juan A. Rodriguez,Juan A. Rodriguez,Sherri Osborne-Lawrence,Sherri Osborne-Lawrence,Nathan P. Metzger,Nathan P. Metzger,Navpreet Chhina,Bruce D. Gaylinn,Michael O. Thorner,E. Louise Thomas,Jimmy D. Bell,Kevin W. Williams,Anthony P. Goldstone,Jeffrey M. Zigman +17 more
TL;DR: It is predicted that the plasma LEAP2/acyl-gh Relin molar ratio may be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose.
Journal ArticleDOI
Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles
TL;DR: It is concluded that celecoxib inhibits calcium responses in VSMCs by enhancing KCNQ5 currents and suppressing L-type calcium currents, which ultimately reduces vascular tone.
Journal ArticleDOI
Ghrelin as a Survival Hormone
TL;DR: An emerging concept in which the endogenous ghrelin system serves an essential function during extreme nutritional and psychological challenges to defend blood glucose, protect body weight, avoid exaggerated depression, and ultimately allow survival is reviewed.
Journal ArticleDOI
Ghrelin's Relationship to Blood Glucose.
TL;DR: The literature suggesting the existence of a blood glucose-ghrelin axis is reviewed and the factors that mediate the glucoregulatory actions of ghrelin are highlighted, especially during metabolic extremes such as starvation and diabetes.