S
Sherri Osborne-Lawrence
Researcher at University of Texas Southwestern Medical Center
Publications - 57
Citations - 4949
Sherri Osborne-Lawrence is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Ghrelin & Orexigenic. The author has an hindex of 29, co-authored 54 publications receiving 4450 citations. Previous affiliations of Sherri Osborne-Lawrence include University of Texas at Dallas & University of Pittsburgh.
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Journal ArticleDOI
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
Ivan S. Yuhanna,Yan Zhu,Blair E. Cox,Lisa Hahner,Sherri Osborne-Lawrence,Ping Lu,Yves L. Marcel,Richard G.W. Anderson,Michael E. Mendelsohn,Helen H. Hobbs,Philip W. Shaul +10 more
TL;DR: It is shown that HDL stimulates endothelial nitric oxide synthase (eNOS) in cultured endothelial cells through a process that requires ApoA-I binding, and the resulting increase in nitric-oxide production might be critical to the atheroprotective properties of HDL and Apo-I.
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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Michael Lutter,Ichiro Sakata,Sherri Osborne-Lawrence,Sherry A. Rovinsky,Jason G. Anderson,Saendy Jung,Shari G. Birnbaum,Masashi Yanagisawa,Joel K. Elmquist,Eric J. Nestler,Jeffrey M. Zigman +10 more
TL;DR: It is found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test, demonstrating a previously unknown function for ghrel in defending against depressive-like symptoms of chronic stress.
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Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
Mario Perello,Ichiro Sakata,Shari G. Birnbaum,Jen Chieh Chuang,Sherri Osborne-Lawrence,Sherry A. Rovinsky,Jakub Woloszyn,Masashi Yanagisawa,Michael Lutter,Jeffrey M. Zigman +9 more
TL;DR: The results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
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Characterization of Kiss1 neurons using transgenic mouse models
Roberta M. Cravo,Lisandra O. Margatho,Lisandra O. Margatho,Sherri Osborne-Lawrence,Jose Donato,Stan D. Atkin,Angie L. Bookout,Sherry A. Rovinsky,Renata Frazão,Charlotte E. Lee,Laurent Gautron,Jeffrey M. Zigman,Carol F. Elias +12 more
TL;DR: The differences observed between the Kiss1 neurons in the preoptic area and the Arc likely represent neuronal evidence for their differential roles in metabolism and reproduction.
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Ghrelin mediates stress-induced food-reward behavior in mice
Jen Chieh Chuang,Mario Perello,Ichiro Sakata,Sherri Osborne-Lawrence,Joseph M. Savitt,Michael Lutter,Jeffrey M. Zigman +6 more
TL;DR: This mouse model has allowed us to ascribe a role for ghrelin-engaged catecholaminergic neurons in stress-induced eating, and to describe a system in which food-reward behavior is monitored in mice after exposure to chronic social defeat stress.