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Bianca Heemskerk
Researcher at Leiden University Medical Center
Publications - 14
Citations - 3310
Bianca Heemskerk is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 13, co-authored 14 publications receiving 2966 citations. Previous affiliations of Bianca Heemskerk include National Institutes of Health.
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Journal ArticleDOI
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
Mojgan Ahmadzadeh,Laura A. Johnson,Bianca Heemskerk,John R. Wunderlich,Mark E. Dudley,Donald E. White,Steven A. Rosenberg +6 more
TL;DR: It is suggested that the tumor microenvironment can lead to up-regulation of PD-1 on tumor-reactive T cells and contribute to impaired antitumor immune responses.
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Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.
Mary E. Morgan,Jolanda H. M. van Bilsen,A Bakker,Bianca Heemskerk,Marco W. Schilham,Franca C. Hartgers,B. G. Elferink,Linda van der Zanden,René R. P. de Vries,Tom W J Huizinga,Tom H. M. Ottenhoff,René E. M. Toes +11 more
TL;DR: The results indicate that FOXP3 expression in humans, unlike mice, may not be specific for cells with a regulatory phenotype and may be only a consequence of activation status.
Journal ArticleDOI
Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes
Laura A. Johnson,Bianca Heemskerk,Daniel J. Powell,Cyrille J. Cohen,Richard A. Morgan,Mark E. Dudley,Paul F. Robbins,Steven A. Rosenberg +7 more
TL;DR: It is demonstrated that the TCR appeared to be the core determinant of MART-1 Ag-specific cellular avidity in these activated T cells and that nonreactive PBMC or TIL could be made tumor-reactive with a specific and predetermined avidity.
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FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions
Mojgan Ahmadzadeh,Aloisio Felipe-Silva,Bianca Heemskerk,Daniel J. Powell,John R. Wunderlich,Maria J. Merino,Steven A. Rosenberg +6 more
TL;DR: It is demonstrated that the tumor-infiltrating CD4 T(reg) cell population is accurately depicted by FOXP3 expression, they selectively accumulate in tumors, and their frequency in peripheral blood does not properly reflect tumor microenvironment.
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High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation.
Marco W. Schilham,Eric C. J. Claas,Wouter van Zaane,Bianca Heemskerk,Jaak M. Vossen,Arjan C. Lankester,René E. M. Toes,Marcela Echavarria,Aloys C.M. Kroes,Maarten J. D. van Tol +9 more
TL;DR: Levels of AdV DNA in serum samples obtained from 36 transplant recipients with stool cultures positive for AdV were measured by polymerase chain reaction (PCR) semiquantitatively by analyzing serial dilutions of the DNA template.