Showing papers in "Human Immunology in 2005"

TL;DR: The results indicate that FOXP3 expression in humans, unlike mice, may not be specific for cells with a regulatory phenotype and may be only a consequence of activation status.

TL;DR: Large numbers of NETs were present directly in the intervillous space of preeclamptic placentae, and their increased presence in preeclampsia suggests that NETs may play a role in the underlying pathology.

TL;DR: The equivalents provided will be useful in guiding searches for unrelated hematopoietic stem cell donors in which patients and/or potential donors are typed by either serology or DNA-based methods and will also serve typing and matching procedures for organ transplant programs where HLA typings from donors and from recipients on waiting lists represent mixtures of serologic and molecular typings.

TL;DR: Data demonstrate that CD4+CD25+ Tregs can exert direct suppressive effects on monocytes/macrophages, thereby affecting subsequent innate and adaptive immune responses.

TL;DR: In this article, a set of 341 white, multiplex T1D families were genotyped for the C1858T single nucleotide polymorphism of PTPN22, and transmission disequilibrium test analysis revealed significant association (p = 0.005) of the T allele with Type 1 diabetes (T1D), rheumatoid arthritis, and systemic lupus erythematosus.

TL;DR: The present study investigated the presence or absence of 16 KIR genes and pseudogenes and subtypes of four genes in 352 members of 77 unrelated Korean families using a PCR-based sequence-specific priming method and determined KIR haplotypes.

TL;DR: Findings have important implications regarding the use of specificities to predict positive crossmatch, to selecting platelet donors for highly sensitized recipients, and analysis of sera for donor specific antibodies.

TL;DR: The comparison of the two ELISA results obtained evidenced that in healthy donors sHLA-G1 molecules can exist in body fluids besides HLA-G5, and both ELISA formats measure reproducibly the amounts of sHLa-G.

TL;DR: A role for HLA class I alleles in susceptibility to and age at onset of T1D is supported and molecular genotyping was performed for 283 multiplex Caucasian families, previously typed for Hla-A and the class II loci.

TL;DR: The results of this study suggest that the human leukocyte antigen class III C4BQ0 significantly increases the risk for autism.

TL;DR: Because alloantibody monitoring becomes extremely important, it will help clinicians to determine a patient's humoral responses against allograft and will therefore direct clinicians to optimize and/or minimize immunosuppressive drug therapy.

TL;DR: It is demonstrated how the types of data generated here can be used to predict elimination or persistence of DSA, and strength of antibody at initiation of treatment and antibody specificity are demonstrated.

TL;DR: An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.

TL;DR: A line of investigation indicates that one or several genes in the human major histocompatibility complex influences reproductive success and for autoimmune diseases during pregnancy, and associations between polymorphisms in the nonclassical HLA class Ib gene, HLA-G, and reproductive outcome have been demonstrated.

TL;DR: IVIG in SLE is indicated either in severe cases that are nonresponsive to other therapeutic modalities, or when SLE can be controlled only with high-dose steroids; in such patients, IVIG thus becomes a useful steroid-sparing agent.

TL;DR: Observations indicate that the downregulation of MHC-II at the cell surface contributes to the immunomodulatory properties of statins and is achieved through disruption of cholesterol-containing microdomains, which are involved in their intracellular transport.

TL;DR: The results reveal an association between B* 57 supertype (B*57s, which includes B*57 and B*58 alleles) and delayed progression to AIDS and the presence of the inhibitory allele KIR3DL1 in combination with the HLA-B* 57s alleles that contain the Bw4-I80 epitope has a highly protective effect against progression toAIDS in Zambian patients.

TL;DR: The results provide additional evidence that in some cases of spontaneous abortions, the women lack the appropriate inhKIRs to interact with the HLA-Cw molecules on trophoblasts and to deliver signals to inhibit natural killer cell activation and protect the embryo.

TL;DR: The features of these cells and their importance in regulation of autoimmunity suggest that NKT cell-based therapies might be an interesting approach for the treatment of autoimmune diseases.

TL;DR: The BTNL2 rs2076530 polymorphism is associated with T1D, RA, and SLE because of its strong linkage disequalibrium with predisposing HLA DQB1-DRB1 haplotypes in Caucasian populations.

TL;DR: Evidence is provided that the combination DQB1*0602/DRB1*150101 is a strong positive marker for severe pulmonary sarcoidosis, and the high linkage disequilibrium between DRB1-1501 and DQB-0602 in Caucasians could be the primary association.

TL;DR: Cord blood transplantation after myeloablative and reduced-intensity conditioning has been successfully demonstrated, resulting in long-term full donor chimerism, decreased Grade 3/4 acute graft-versus-host disease and improvements in overall survival.

TL;DR: An overview and critical discussion of mechanisms that may be responsible of IVIG effects in ITP are provided and a large fraction of the benefit provided by IVIG may be the result of competitive inhibition of neonatal Fc receptor (FcRn) and IVIG-induced acceleration of antiplatelet antibody elimination.

TL;DR: It is suggested that DRB1*0803 and DQB1*0601 alleles are associated with disease progression of TB in Koreans, exerting influence on the development of drug resistance, severe disease, and recurrent disease.

TL;DR: A weaker association between AS and HLA-B27 in Algerians than in that reported for European patients is revealed, suggesting a possible influence of other genetic/environmental determinants in the studied population.

TL;DR: IL-6 and IL-10 polymorphic features, together with other factors known to affect the risk of aGVHD, were subjected to multivariate analyses and confirmed the independent contribution of recipient IL- 10 GCC/GCC and donor IL-6 GG genotypes to the risk.

TL;DR: A novel cell-independent assay for assessment of complement-activating panel reactivity and a highly significant association between absolute [C4d]FlowPRA and CDC-PRA levels is found, suggesting that detection of C4 split product deposition to FlowPRA beads may represent an attractive HLA-specific and time-effective alternative to CDC- PRA screening.

TL;DR: The results suggest that the T allele may be a factor protecting against development of TB once the immune system recognizes M. tuberculosis (i.e., TST+ individuals), whereas the C allele mayBe a risk factor for development of overt TB.

TL;DR: An HLAMatchmaker-based analysis of the reactivity of human mAbs will increase the understanding of the structural definition of HLA epitopes and their reactivity with alloantibodies.

TL;DR: It is proposed that in generating a T cell repertoire with a sufficiently narrow responsive for self-MHC, positive thymic selection limits the capacity to recognize allogeneic MHC molecules whose structure and sequence have diverged extensively.