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Bibhuti R. DasGupta
Researcher at University of Wisconsin-Madison
Publications - 79
Citations - 5763
Bibhuti R. DasGupta is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Clostridium botulinum & Neurotoxin. The author has an hindex of 29, co-authored 79 publications receiving 5608 citations.
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Journal ArticleDOI
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
Giampietro Schiavo,Fabio Benfenati,Bernard Poulain,Ornella Rossetto,Patrizia Polverino de Laureto,Bibhuti R. DasGupta,Cesare Montecucco +6 more
TL;DR: The results indicate that tetanus and botulinum B neurotoxins block neurotransmitter release by cleaving synaptobrevin-2, a protein that, on the basis of the results, seems to play a key part in neurotransmitterRelease.
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Crystal structure of botulinum neurotoxin type A and implications for toxicity.
TL;DR: The crystal structure of the entire 1,285 amino acid di-chain neurotoxin was determined and the toxin appears as a hybrid of varied structural motifs and suggests a modular assembly of functional subunits to yield pathogenesis.
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Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
Giampietro Schiavo,Annalisa Santucci,Bibhuti R. DasGupta,Prashant P. Mehta,Jaime Jontes,Fabio Benfenati,Michael Wilson,Cesare Montecucco +7 more
TL;DR: Results indicate that the carboxyl‐terminal region of SNAP‐25 plays a crucial role in the multi‐protein complex that mediates vesicle docking and fusion at the nerve terminal.
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Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.
David H. Hoch,Miryam Romero-Mira,Barbara E. Ehrlich,Alan Finkelstein,Bibhuti R. DasGupta,Lance L. Simpson +5 more
TL;DR: These findings support the hypothesis that the active fragments of botulinum neurotoxin and tetanus toxin, like that of diphtheria toxin, are translocated across the membranes of acidic vesicles.
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N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis
TL;DR: NSF-catalyzed activation of SNARE proteins may reorganize membranes to generate a vesicle-plasma membrane prefusion intermediate that is poised for conversion to full fusion by Ca2+-dependent mechanisms.