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Bichitra K. Biswal
Researcher at University of Alberta
Publications - 45
Citations - 795
Bichitra K. Biswal is an academic researcher from University of Alberta. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 13, co-authored 37 publications receiving 705 citations. Previous affiliations of Bichitra K. Biswal include Indian Institute of Science & Canadian Institutes of Health Research.
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Journal ArticleDOI
Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
Bichitra K. Biswal,Maia M. Cherney,Meitian Wang,Laval Chan,Constantin G. Yannopoulos,Darius Bilimoria,Olivier Nicolas,Jean Bedard,Michael N.G. James +8 more
TL;DR: The structures of the NS5B polymerase/non-nucleoside inhibitor complexes bind at a common binding site, which is nearly 35 Å away from the polymerase active site and is located in the thumb domain, and the enzyme inhibitor complexes are stabilized by hydrogen bonding and van der Waals interactions.
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Mammalian zona pellucida glycoproteins: structure and function during fertilization.
Satish K. Gupta,Beena Bhandari,Abhinav Shrestha,Bichitra K. Biswal,Chetna Palaniappan,Sudha Saryu Malhotra,Neha Gupta +6 more
TL;DR: In humans more than one zona protein binds to spermatozoa and induces an acrosome reaction, and Sialyl-Lewisx sequence present on both N- and O-glycans of human ZP play an important role in human sperm–egg binding.
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Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Bichitra K. Biswal,Meitian Wang,Maia M. Cherney,Laval Chan,Constantin G. Yannopoulos,Darius Bilimoria,Jean Bedard,Michael N.G. James +7 more
TL;DR: The details of NS5B polymerase/inhibitor binding interactions coupled with the observed induced conformational changes provide new insights into the design of novel NNIs of HCV.
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Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S
Enrico Weidauer,Yoshiyuki Yasuda,Bichitra K. Biswal,Maia Cherny,Michael N.G. James,Dieter Brömme +5 more
TL;DR: It is demonstrated that clinically potent gold derivatives inhibit cathepsins K and S in in vitro and cell-based assays and may explain the therapeutic efficacy of these drugs.
Journal ArticleDOI
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
Bichitra K. Biswal,Christophe Morisseau,Grace Garen,Maia M. Cherney,Craig R. Garen,Chunying Niu,Bruce D. Hammock,Michael N.G. James +7 more
TL;DR: These findings have not only shed light on the enzyme mechanism but also have opened a path for the development of potent inhibitors with good pharmacokinetic profiles against all Mtb EHs of the alpha/beta type.