Bieke Dejaegher

TL;DR: The evolution of the regulations and guidelines on the quality control of herbal medicines is considered, and the established analytical techniques for herbal fingerprinting are reviewed with an emphasis on the most recent developments, such as miniaturized techniques, new stationary phases, analysis at high temperatures and multi-dimensional chromatography.

TL;DR: In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed and an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results are discussed.

TL;DR: In this review, the definitions of ruggedness and robustness are given, followed by a short explanation of the different approaches applied to examine the ruggedness or the robustness of an analytical method.

TL;DR: In this review, hydrophilic interaction liquid chromatographic applications for pharmaceutical analysis are discussed and the advantages and drawbacks of HILIC are discussed, as well as the method validation issues, when executed.

TL;DR: It was demonstrated that Raman spectroscopy is a suitable PAT tool for the endpoint control of a powder blending process and not only allowed in-line and real-time monitoring of the blend homogeneity, but also helped to understand the process better in combination with experimental design.