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A. Burggraeve
Researcher at Ghent University
Publications - 11
Citations - 1293
A. Burggraeve is an academic researcher from Ghent University. The author has contributed to research in topics: Process analytical technology & Raman spectroscopy. The author has an hindex of 11, co-authored 11 publications receiving 1129 citations. Previous affiliations of A. Burggraeve include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes.
TL;DR: This paper aims at reviewing the use of Raman and NIR spectroscopy in the PAT setting, i.e., during processing, with special emphasis in pharmaceutics and dosage forms.
Journal ArticleDOI
In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools
T. De Beer,P. Vercruysse,A. Burggraeve,T. Quinten,Jin Ouyang,Xuan Zhang,Chris Vervaet,J.P. Remon,Willy Baeyens +8 more
TL;DR: Combining Raman and NIR spectroscopy for the simultaneous monitoring of freeze drying allows monitoring almost all critical freeze drying process aspects and provided mutual confirmation of specific conclusions.
Journal ArticleDOI
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process.
T. De Beer,Cédric Bodson,Bieke Dejaegher,Beata Walczak,P. Vercruysse,A. Burggraeve,A. Lemos,Luc Delattre,Y. Vander Heyden,Jean Paul Remon,Chris Vervaet,Willy R. G. Baeyens +11 more
TL;DR: It was demonstrated that Raman spectroscopy is a suitable PAT tool for the endpoint control of a powder blending process and not only allowed in-line and real-time monitoring of the blend homogeneity, but also helped to understand the process better in combination with experimental design.
Journal ArticleDOI
Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review
TL;DR: An overview of the process analytical technologies used during fluid bed granulation to monitor and control the process is given and analysis and modeling tools enabling the extraction of the relevant information from the complex data collected during granulation and the control of theprocess are highlighted.
Journal ArticleDOI
Particle sizing measurements in pharmaceutical applications: comparison of in-process methods versus off-line methods
Ana Tavares da Silva,A. Burggraeve,Quenten Denon,Paul Van der Meeren,Niklas Sandler,Tom Van Den Kerkhof,Mario Hellings,Chris Vervaet,Jean Paul Remon,João A. Lopes,Thomas De Beer +10 more
TL;DR: Several in-process techniques for particle size determination are reviewed and compared to well-known and widespread off-line reference methods and a theoretical explanation of the working mechanism behind each sizing technique is presented.