T
T. De Beer
Researcher at Ghent University
Publications - 96
Citations - 4225
T. De Beer is an academic researcher from Ghent University. The author has contributed to research in topics: Granulation & Controlled release. The author has an hindex of 31, co-authored 96 publications receiving 3543 citations. Previous affiliations of T. De Beer include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes.
TL;DR: This paper aims at reviewing the use of Raman and NIR spectroscopy in the PAT setting, i.e., during processing, with special emphasis in pharmaceutics and dosage forms.
Journal ArticleDOI
Continuous twin screw granulation: Influence of process variables on granule and tablet quality
Jurgen Vercruysse,D. Córdoba Díaz,Elisabeth Peeters,Margot Fonteyne,U. Delaet,I. Van Assche,T. De Beer,Jean Paul Remon,Chris Vervaet +8 more
TL;DR: The results showed that the quality of granules and tablets can be optimized by adjusting specific process variables during a granulation process using a continuous twin screw granulator.
Journal ArticleDOI
In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools
T. De Beer,P. Vercruysse,A. Burggraeve,T. Quinten,Jin Ouyang,Xuan Zhang,Chris Vervaet,J.P. Remon,Willy Baeyens +8 more
TL;DR: Combining Raman and NIR spectroscopy for the simultaneous monitoring of freeze drying allows monitoring almost all critical freeze drying process aspects and provided mutual confirmation of specific conclusions.
Journal ArticleDOI
Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion.
A. Almeida,Sam Possemiers,Matthieu Boone,T. De Beer,T. Quinten,L. Van Hoorebeke,J.P. Remon,Chris Vervaet +7 more
TL;DR: The Simulator of the Human Intestinal Microbial Ecosystem (SHIME) used to evaluate the stability of EVA during gastrointestinal transit showed that EVA was not modified during GI transit, nor did it affect the GI ecosystem following oral administration.
Journal ArticleDOI
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process.
T. De Beer,Cédric Bodson,Bieke Dejaegher,Beata Walczak,P. Vercruysse,A. Burggraeve,A. Lemos,Luc Delattre,Y. Vander Heyden,Jean Paul Remon,Chris Vervaet,Willy R. G. Baeyens +11 more
TL;DR: It was demonstrated that Raman spectroscopy is a suitable PAT tool for the endpoint control of a powder blending process and not only allowed in-line and real-time monitoring of the blend homogeneity, but also helped to understand the process better in combination with experimental design.