Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review

Flora of Turkey and the East Aegean Islands.

Differently substituted flavanones were isolated from Leguminosae and their antibacterial activity was comparatively studied against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method. The structure-activity relationship has indicated that 2',4'- or 2',6'-dihydroxylation of the B ring and 5,7-dihydroxylation of the A ring in the flavanone structure are important for significant anti-MRSA activity and that substitution with a certain aliphatic group at the 6- or 8-position also enhances the activity. Among the thirteen flavanones tested, tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml. The present hydroxyflavanones would be useful in the phytotherapeutic strategy against MRSA infections.

Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.

Ellagitannins, ellagic acid and vascular health

Lignans neolignans, and related compounds

Disposable electrochemical biosensor for the detection of the interaction between DNA and lycorine based on guanine and adenine signals.

The antimicrobial and cytotoxic activities of n-hexane, methanol, ethanol, ethyl acetate and water extracts of Ceratonia siliqua L. leaves were evaluated in this study. The antimicrobial activities of the extracts were reported against Escherichia coli ATCC 29998, Escherichia coli ATCC 25922, Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538P, Staphylococcus aureus ATCC6538P, Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Salmonella thyphimurium CCM 5445, Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212, Pseudomonas aeroginosa ATCC 27853 as bacteria and Candida albicans ATCC 10239 as yeast-like fungi by the disc diffusion method. The cytotoxic activity of the extracts was evaluated by the brine shrimp lethality bioassay. The ethanol, methanol and water extracts showed cytotoxic activity against brine shrimp.

https://journals.tubitak.gov.tr/biology/issues/biy-02-26-4/biy-26-4-2-0111-4.pdf

Antimicrobial and Cytotoxic Activities of Ceratonia siliqua L. Extracts

The aim of this study was to compare the effectiveness of gel formulations containing arbutin, synthetic ellagic acid and plant extracts that contain ellagic acid, on patients with melasma. Thirty patients who applied to Ege University Medical Faculty, Department of Dermatology, were included in the study. A signed consent was obtained from each patient prior to study. Patients whose type of melasma was determined via Wood's lamp were randomized to groups of arbutin, synthetic ellagic acid and plant extract containing natural ellagic acid. The pigment density of patients was evaluated via Mexameter before and after the treatment. The approval of the Institutional Ethics Committee of Ege University was obtained before the study. Wilcoxon and Kruskal-Wallis tests were used in the statistical analysis. Nine of 10 patients, for whom synthetic ellagic acid was started, completed the study. A decrease in the level of melanin was determined in eight of these nine patients (P = 0.038). A significant decrease in the level of melanin was also determined in all 10 patients who used plant extract containing ellagic acid (P = 0.05). A significant response was obtained from all of 10 patients who used arbutin. The difference between pre- and post-treatment levels of melanin was statistically significant (P = 0.05). Formulations prepared with plant extracts containing ellagic acid was found effective on melasma, similar to the formulations containing synthetic ellagic acid and arbutin. This material that is not yet being used widespread commercially on melasma could be an effective alternative for treatment of melasma.

Bijen Kivçak

Papers

Disposable electrochemical biosensor for the detection of the interaction between DNA and lycorine based on guanine and adenine signals.

Antimicrobial and Cytotoxic Activities of Ceratonia siliqua L. Extracts

Efficiency of ellagic acid and arbutin in melasma: A randomized, prospective, open‐label study

Synthesis, characterization and studies on antioxidant activity of silver nanoparticles using Asphodelus aestivus Brot. aerial part extract

Antioxidant activity of Arbutus unedo leaves.