B
Bin Di
Researcher at Chinese Ministry of Education
Publications - 9
Citations - 252
Bin Di is an academic researcher from Chinese Ministry of Education. The author has contributed to research in topics: Inflammasome & Pyrin domain. The author has an hindex of 6, co-authored 9 publications receiving 88 citations. Previous affiliations of Bin Di include China Pharmaceutical University.
Papers
More filters
Journal ArticleDOI
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies.
TL;DR: In this article, the authors introduce the canonical NLRP3 inflammasome activation pathway and review the cellular/molecular mechanisms of NNBP3 activation by SARS-CoV-2 infection (e.g., viroporins, ion flux and the complement cascade).
Journal ArticleDOI
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
TL;DR: DDO-7263 improved the behavioral abnormalities induced by MPTP in mice, significantly attenuated chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra and striatum of the mouse brain and inhibited the secretion of inflammatory factors.
Journal ArticleDOI
Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors.
TL;DR: The cellular/molecular mechanisms of the NEK7-licensed NLRP3 inflammasome activation are described and the potential inhibitors that can selectively and effectively modulate either the NEk7-NLRP3 complex itself or the related molecular/cellular events are detailed.
Journal ArticleDOI
Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis.
Zhen Dai,Zhen Dai,Chen Xiaoyi,Chen Xiaoyi,Lu-yan An,Lu-yan An,Cui-Cui Li,Cui-Cui Li,Ni Zhao,Ni Zhao,Fan Yang,Fan Yang,Song-Tao You,Song-Tao You,Chen-Zhi Hou,Chen-Zhi Hou,Kan Li,Kan Li,Cheng Jiang,Cheng Jiang,Qidong You,Bin Di,Bin Di,Li-Li Xu,Li-Li Xu +24 more
TL;DR: In this paper, a series of tetrahydroquinoline inhibitors of the NLRP3 inflammasome were synthesized, and compound 6 exhibited optimal inhibitory activity.
Journal ArticleDOI
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
TL;DR: A novel effective Nrf2 activator, DDO7232, is identified, which showed protective effects on NCM460 cells and therapeutic effects on DSS-induced colitis in mice and provided an effective therapeutic option for the treatment of UC.