Bin Feng

TL;DR: It is found that Myc haploinsufficient (Myc(+/-) mice exhibit increased lifespan and appear to be more active, with a higher metabolic rate and healthier lipid metabolism, and a gene expression signature enriched for metabolic and immune processes.

TL;DR: Free‐fatty acids can activate endoplasmic reticulum (ER) stress pathway by examination of ER stress sensor activation and marker gene expression and results indicate that ER stress pathway is a key mediator for FFA‐induced inflammation and insulin resistance in adipocytes with PERK and IKKβ as the critical signaling components.

TL;DR: Intraperitoneal injection of clodronate liposomes reduces visceral adipose tissue macrophages, improves systemic glucose homeostasis and insulin sensitivity in DIO mice, which can be partially attributable to increased adiponectin levels.

TL;DR: It is shown that expression of MKP-3 is markedly increased in the liver of diet-induced obese mice, and inhibition of MKK phosphatase-3 activity may provide new therapies for type 2 diabetes mellitus, suggesting that inhibition of the protein in vivo is an important regulator of hepatic gluconeogenesis in vivo.

TL;DR: Increased hepatic ERK activity in DIO mice may contribute to increased liver glycogen content and decreased energy expenditure in obesity, and knocking down ERK expression in the liver of diet induced obese (DIO) mice improves systemic insulin and glucose tolerance.