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Bingbing X. Li
Researcher at Oregon Health & Science University
Publications - 31
Citations - 792
Bingbing X. Li is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: CREB & Transcription factor. The author has an hindex of 11, co-authored 28 publications receiving 636 citations. Previous affiliations of Bingbing X. Li include Health Science University & Purdue University.
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Journal ArticleDOI
Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors
TL;DR: A protein trio conserved across eukaryotes thus mediates normal, in vivo sensory neuron morphogenesis and delivers morphogenic secretory traffic along polarized actin filaments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.
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Targeting CREB for cancer therapy: friend or foe.
TL;DR: The results suggest that CREB is a suitable transcription factor for drug targeting and therefore targeting CREB could represent a novel strategy for cancer therapy.
Journal ArticleDOI
Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity
Fuchun Xie,Bingbing X. Li,Alina Kassenbrock,Changhui Xue,Xiaoyan Wang,David Z. Qian,Rosalie C. Sears,Xiangshu Xiao +7 more
TL;DR: Biological evaluations of a series of structural congeners of naphthamide 3a uncovered compound 3i (666-15) as a potent and selective inhibitor of CREB-mediated gene transcription and potently inhibited cancer cell growth without harming normal cells.
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Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics.
TL;DR: Recent progress in this area with reported inhibitors of Hsp60 includes mizoribine, epolactaene, myrtucommulone, stephacidin B, and avrainvillamide while the latter includes o-carboranylphenoxyacetanilides and gold (III) porphyrins.
Journal ArticleDOI
Systemic Inhibition of CREB is Well-tolerated in vivo.
Bingbing X. Li,Ryan T. Gardner,Changhui Xue,David Z. Qian,Fuchun Xie,George Thomas,Steven C. Kazmierczak,Beth A. Habecker,Xiangshu Xiao +8 more
TL;DR: For the first time, results demonstrate that pharmacological inhibition of CREB is well-tolerated in vivo and indicate that such inhibitors should be promising cancer therapeutics.