Changhui Xue

TL;DR: The novel biological relationship between HDAC4 and HIF1α presented here suggests a potential role for the deacetylase enzyme in regulating HIF-1 cancer cell response to hypoxia and presents a more specific molecular target of inhibition.

TL;DR: A novel biological consequence upon HIF1α-p300 interaction is demonstrated, in which Hif1α can be stabilized by p300 via Lys-709 acetylation, which increases the protein stability and decreases polyubiquitination in both normoxia and hypoxia.

TL;DR: Biological evaluations of a series of structural congeners of naphthamide 3a uncovered compound 3i (666-15) as a potent and selective inhibitor of CREB-mediated gene transcription and potently inhibited cancer cell growth without harming normal cells.

TL;DR: Novel mechanistic understandings in cancer cell chemotherapeutic sensitivity and resistance can optimize treatment and improve patient outcome in prostate cancer therapeutics.

TL;DR: It is shown that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalUTamide.