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Bixiong C. Xu
Researcher at Ohio University
Publications - 3
Citations - 935
Bixiong C. Xu is an academic researcher from Ohio University. The author has contributed to research in topics: Growth hormone receptor & Receptor tyrosine kinase. The author has an hindex of 3, co-authored 3 publications receiving 900 citations.
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Journal ArticleDOI
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
Yihua Zhou,Bixiong C. Xu,Hiralal G. Maheshwari,Li He,Michael Reed,Maria Lozykowski,Shigeru Okada,Lori Cataldo,Karen Coschigamo,Thomas Wagner,Gerhard Baumann,John J. Kopchick +11 more
TL;DR: The findings indicate that the G HR/BP-deficient mouse (Laron mouse) is a suitable model for human Laron syndrome that will prove useful for the elucidation of many aspects of GHR/BP function that cannot be obtained in humans.
Journal ArticleDOI
Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.
TL;DR: It is deduced that Y332, Y487, Y534, Y 566, and Y627 are pGHR tyrosine phosphorylation sites, which agrees with a previous report that Janus kinase 2 activation is independent of GHR tyrorosineosphorylation.
Journal ArticleDOI
Growth Hormone Promotes the Association of Transcription Factor STAT5 with the Growth Hormone Receptor
TL;DR: It is demonstrated that GH induces rapid tyrosine phosphorylation of different isoforms of STAT5 in mouse L cells stably transfected with a cDNA encoding porcine GHR (pGHR) and the GH-dependent interaction of a particular STAT5 with tyrosinesine-phosphorylated GHR may play an important role in GH-mediated signal transduction.