B
Blakely B. O'Connor
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 12
Citations - 752
Blakely B. O'Connor is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Myocyte & Actin. The author has an hindex of 9, co-authored 12 publications receiving 414 citations. Previous affiliations of Blakely B. O'Connor include Harvard University.
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Journal ArticleDOI
Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Richard M. Novak,Miles Ingram,Susan Marquez,Debarun Das,Aaron Delahanty,Anna Herland,Anna Herland,Ben M. Maoz,Ben M. Maoz,Ben M. Maoz,Sauveur S. F. Jeanty,Mahadevabharath R. Somayaji,Morgan Burt,Elizabeth Calamari,Angeliki Chalkiadaki,Alexander Cho,Youngjae Choe,David B. Chou,David B. Chou,Michael J. Cronce,Stephanie Dauth,Stephanie Dauth,Toni Divic,Jose Fernandez-Alcon,Thomas C. Ferrante,John P. Ferrier,John P. Ferrier,Edward A. FitzGerald,Rachel Fleming,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Thomas Grevesse,Thomas Grevesse,Josue A. Goss,Josue A. Goss,Tiama Hamkins-Indik,Olivier Y.F. Henry,Chris Hinojosa,Tessa Huffstater,Kyung-Jin Jang,Ville J. Kujala,Ville J. Kujala,Lian Leng,Robert Mannix,Robert Mannix,Yuka Milton,Janna Nawroth,Janna Nawroth,Bret Nestor,Carlos F. Ng,Blakely B. O'Connor,Blakely B. O'Connor,Tae-Eun Park,Henry Sanchez,Josiah Sliz,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Guy Robert Thompson,George J. Touloumes,George J. Touloumes,Zachary Tranchemontagne,Norman Wen,Moran Yadid,Moran Yadid,Anthony Bahinski,Anthony Bahinski,Geraldine A. Hamilton,Daniel Levner,Oren Levy,Andrzej Przekwas,Rachelle Prantil-Baun,Kevin Kit Parker,Kevin Kit Parker,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +76 more
TL;DR: An 'interrogator' that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator is described.
Journal ArticleDOI
Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing.
Seungkuk Ahn,Christophe O. Chantre,A.R. Gannon,Johan Ulrik Lind,Patrick H. Campbell,Thomas Grevesse,Blakely B. O'Connor,Kevin Kit Parker +7 more
TL;DR: The development of an entirely plant‐based nanofibrous dressing comprised of cellulose acetate (CA) and soy protein hydrolysate (SPH) using rotary jet spinning affirm the potential of CA/SPH nan ofibers as a novel wound dressing.
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Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening
Johan Ulrik Lind,Moran Yadid,Ian Perkins,Blakely B. O'Connor,Feyisayo Eweje,Christophe O. Chantre,Matthew A. Hemphill,Hongyan Yuan,Patrick H. Campbell,Joost J. Vlassak,Kevin Kit Parker +10 more
TL;DR: An instrumented 24-well plate platform for higher-throughput studies of engineered human stem cell-derived cardiac muscle tissues that recapitulate the laminar structure of the native ventricle and regulates the temporal onset of cardiac drug responses by modulating endothelial barrier permeability in vitro.
Journal ArticleDOI
Muscle tissue engineering in fibrous gelatin: implications for meat analogs.
Luke A. MacQueen,Charles G. Alver,Charles G. Alver,Christophe O. Chantre,Christophe O. Chantre,Seungkuk Ahn,Seungkuk Ahn,Luca Cera,Luca Cera,Grant M. Gonzalez,Grant M. Gonzalez,Blakely B. O'Connor,Blakely B. O'Connor,Daniel J. Drennan,Daniel J. Drennan,Michael M. Peters,Michael M. Peters,Sarah E. Motta,Sarah E. Motta,John F. Zimmerman,John F. Zimmerman,Kevin Kit Parker,Kevin Kit Parker +22 more
TL;DR: Histology, scanning electron microscopy, and mechanical testing demonstrated that cultured muscle lacked the mature contractile architecture observed in natural muscle but recapitulated some of the structural and mechanical features measured in meat products.
Journal ArticleDOI
A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility
Alexander P. Nesmith,Matthew A. Wagner,Francesco S. Pasqualini,Blakely B. O'Connor,Mark J. Pincus,Paul R. August,Kevin Kit Parker +6 more
TL;DR: Using a tongue-inspired in vitro platform, Nesmith et al. demonstrate that DMD myoblasts fail to align and polarize with respect to extracellular matrix cues in the same manner as healthy myoblast, resulting in diminished myotube formation and weaker contractile strength.