S
Sauveur S. F. Jeanty
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 5
Citations - 1683
Sauveur S. F. Jeanty is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Gene & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 5 publications receiving 1181 citations. Previous affiliations of Sauveur S. F. Jeanty include Harvard University.
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Journal ArticleDOI
Highly multiplexed subcellular RNA sequencing in situ.
Je-Hyuk Lee,Evan R. Daugharthy,Jonathan Scheiman,Reza Kalhor,Joyce L. Yang,Thomas C. Ferrante,Richard C. Terry,Sauveur S. F. Jeanty,Chao Li,Ryoji Amamoto,Derek T. Peters,Brian M. Turczyk,Adam H. Marblestone,Samuel A. Inverso,Amy Bernard,Prashant Mali,Xavier Rios,John Aach,George M. Church +18 more
TL;DR: FISSEQ is compatible with tissue sections and whole-mount embryos and reduces the limitations of optical resolution and noisy signals on single-molecule detection, and can be used to investigate cellular phenotype, gene regulation, and environment in situ.
Journal ArticleDOI
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip
Samira Musah,Akiko Mammoto,Thomas C. Ferrante,Sauveur S. F. Jeanty,Mariko Hirano-Kobayashi,Mariko Hirano-Kobayashi,Tadanori Mammoto,Kristen Roberts,Seyoon Chung,Richard M. Novak,Miles Ingram,Tohid Fatanat-Didar,Sandeep T. Koshy,James C. Weaver,George M. Church,Donald E. Ingber +15 more
TL;DR: An efficient (> 90%) and chemically defined method for directing the differentiation of human induced pluripotent stem cells into podocytes that express markers of the mature phenotype and that exhibit primary and secondary foot processes is demonstrated.
Journal ArticleDOI
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.
Anna Herland,Anna Herland,Anna Herland,Ben M. Maoz,Debarun Das,Mahadevabharath R. Somayaji,Rachelle Prantil-Baun,Richard M. Novak,Michael J. Cronce,Tessa Huffstater,Sauveur S. F. Jeanty,Miles Ingram,Angeliki Chalkiadaki,David B. Chou,Susan Marquez,Aaron Delahanty,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Yuka Milton,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Oren Levy,Kevin Kit Parker,Kevin Kit Parker,Andrzej Przekwas,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +28 more
TL;DR: Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.
Journal ArticleDOI
Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Richard M. Novak,Miles Ingram,Susan Marquez,Debarun Das,Aaron Delahanty,Anna Herland,Anna Herland,Ben M. Maoz,Ben M. Maoz,Ben M. Maoz,Sauveur S. F. Jeanty,Mahadevabharath R. Somayaji,Morgan Burt,Elizabeth Calamari,Angeliki Chalkiadaki,Alexander Cho,Youngjae Choe,David B. Chou,David B. Chou,Michael J. Cronce,Stephanie Dauth,Stephanie Dauth,Toni Divic,Jose Fernandez-Alcon,Thomas C. Ferrante,John P. Ferrier,John P. Ferrier,Edward A. FitzGerald,Rachel Fleming,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Thomas Grevesse,Thomas Grevesse,Josue A. Goss,Josue A. Goss,Tiama Hamkins-Indik,Olivier Y.F. Henry,Chris Hinojosa,Tessa Huffstater,Kyung-Jin Jang,Ville J. Kujala,Ville J. Kujala,Lian Leng,Robert Mannix,Robert Mannix,Yuka Milton,Janna Nawroth,Janna Nawroth,Bret Nestor,Carlos F. Ng,Blakely B. O'Connor,Blakely B. O'Connor,Tae-Eun Park,Henry Sanchez,Josiah Sliz,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Guy Robert Thompson,George J. Touloumes,George J. Touloumes,Zachary Tranchemontagne,Norman Wen,Moran Yadid,Moran Yadid,Anthony Bahinski,Anthony Bahinski,Geraldine A. Hamilton,Daniel Levner,Oren Levy,Andrzej Przekwas,Rachelle Prantil-Baun,Kevin Kit Parker,Kevin Kit Parker,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +76 more
TL;DR: An 'interrogator' that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator is described.
Posted ContentDOI
A robotic platform for fluidically-linked human body-on-chips experimentation
Richard M. Novak,Miles Ingram,Susan Clauson,Debarun Das,Aaron Delahanty,Anna Herland,Ben M. Maoz,Ben M. Maoz,Sauveur S. F. Jeanty,Mahadevabharath R. Somayaji,Morgan Burt,Elizabeth Calamari,Angeliki Chalkiadaki,Alexander Cho,Youngjae Choe,David B. Chou,David B. Chou,Michael J. Cronce,Stephanie Dauth,Stephanie Dauth,Toni Divic,Jose Fernandez-Alcon,Thomas C. Ferrante,John P. Ferrier,John P. Ferrier,Edward A. FitzGerald,Rachel Fleming,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Thomas Grevesse,Thomas Grevesse,Josue A. Goss,Josue A. Goss,Tiama Hamkins-Indik,Olivier Y.F. Henry,Chris Hinojosa,Tessa Huffstater,Kyung-Jin Jang,Ville J. Kujala,Ville J. Kujala,Lian Leng,Robert Mannix,Robert Mannix,Yuka Milton,Janna Nawroth,Janna Nawroth,Bret Nestor,Carlos F. Ng,Blakely B. O'Connor,Blakely B. O'Connor,Tae-Eun Park,Henry Sanchez,Josiah Sliz,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Ben Swenor,Guy Robert Thompson,George J. Touloumes,George J. Touloumes,Zachary Tranchemontagne,Norman Wen,Moran Yadid,Moran Yadid,Anthony Bahinski,Anthony Bahinski,Geraldine A. Hamilton,Daniel Levner,Oren Levy,Andrzej Przekwas,Rachelle Prantil-Baun,Kevin Kit Parker,Kevin Kit Parker,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +74 more
TL;DR: This automated culture platform enables non-invasive imaging of cells within human Organ Chips and repeated sampling of both the vascular and interstitial compartments without compromising fluidic coupling, which should facilitate future HuBoc studies and pharmacokinetics (PK) analysis in vitro.