Norman Wen

TL;DR: A neurovascular unit is created that recapitulates complex BBB functions, provides a platform for modeling inheritable neurological disorders, and advances drug screening, as well as personalized medicine.

TL;DR: An 'interrogator' that employs liquid-handling robotics, custom software and an integrated mobile microscope for the automated culture, perfusion, medium addition, fluidic linking, sample collection and in situ microscopy imaging of up to ten organ chips inside a standard tissue-culture incubator is described.

TL;DR: The results show that the vascular system has specific maturation effects on spinal cord neural tissue, and the use of Organ-Chips can move stem cell models closer to an in vivo condition.

TL;DR: In this article, a subset of optically clear, elastomeric, styrenic block copolymers based on styrene-ethylene-butylene-styrene (SETH) was shown to exhibit reduced absorption of small hydrophobic molecules and drug compounds compared to PDMS and that they can be fabricated into microfluidic devices with fine features and the flexibility required for Organ Chips using mass production techniques of injection molding and extrusion.

TL;DR: An organomimetic device includes a microfluidic device that can be used to culture cells in its micro-fluid channels as discussed by the authors, which can be part of a dynamic system that can apply mechanical forces to the cells by modulating the micro fluid and the flow of fluid through the micro fluids channels.