Hongyan Yuan

TL;DR: This study combined patient-derived and genetically engineered induced pluripotent stem cells (iPSCs) with tissue engineering to elucidate the pathophysiology underlying the cardiomyopathy of Barth syndrome, a mitochondrial disorder caused by mutation of the gene encoding tafazzin (TAZ).

TL;DR: This work investigates the interactions of graphene and few-layer graphene (FLG) microsheets with three cell types and with model lipid bilayers by combining coarse-grained molecular dynamics (MD), all-atom MD, analytical modeling, confocal fluorescence imaging, and electron microscopic imaging and proposed mechanism allows cellular uptake of even large multilayer sheets of micrometer-scale lateral dimension.

TL;DR: Six functional inks are designed, based on piezo-resistive, high conductance, and biocompatible soft materials that enable integration of soft strain gauge sensors within micro-architectures that guide the self-assembly of physio-mimetic laminar cardiac tissues via multi-material 3D printing.

TL;DR: In this article, a tissue-engineered ray was constructed from rat cardiomyocytes on an elastomeric body enclosing a microfabricated gold skeleton to mimic the fin deflection patterns of batoid fish.

TL;DR: Using an efficient coarse-grained molecular dynamics model, a free energy analysis reveals that NP size primarily determines whether endocytosis can complete, while NP shape breaks the symmetry of curvature energy landscape and hence dictates the endocytic pathway and the angle of entry.