Blanche Young

TL;DR: Data indicate that cells present at prospective joint sites and expressing Gdf5 constitute a distinct cohort of progenitor cells responsible for limb joint formation, which appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation.

TL;DR: In the tendon, the development of mature mechanical properties is dependent on the assembly of a tendon-specific extracellular matrix, which is synthesized by the tendon fibroblasts and composed of collagen fibrils organized as fibers, as well as fibril-associated collagenous and non-collagenous proteins.

TL;DR: Kif3a and primary cilia make unique contributions to cranial base development and synchondrosis growth plate function and cause abnormal topography of hedgehog signaling, growth plate dysfunction, and un-physiologic responses and processes in perichondrial tissues, including ectopic cartilage formation and excessive intramembranous ossification.

TL;DR: Indian hedgehog is very important for TMJ development, where it appears to regulate growth and elongation events, condylar cartilage phenotype, and chondroprogenitor cell function.

TL;DR: expression of types XII and XIV collagens in cornea development demonstrated that type XII collagen mRNA levels are constant throughout development while type XIV mRNA is highest in early embryonic stages, decreasing significantly by hatching, which suggest type XI collagen may have a role in development of stromal architecture and maintenance of fibril organization.