B
Blandine Guignard
Researcher at Centre national de la recherche scientifique
Publications - 4
Citations - 551
Blandine Guignard is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Oligodendrocyte & Remyelination. The author has an hindex of 4, co-authored 4 publications receiving 513 citations.
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Journal ArticleDOI
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging.
Laura A. Harsan,Patrick Poulet,Blandine Guignard,Jérôme Steibel,Nathalie Parizel,Paulo Loureiro de Sousa,Nelly Boehm,Daniel Grucker,M. Said Ghandour +8 more
TL;DR: It is shown clearly that myelination and axonal changes play a role in the degree of diffusion anisotropy, because FA was significantly decreased in dysmyelinated brain.
Journal ArticleDOI
Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging
Laura A. Harsan,Jérôme Steibel,Anita Zaremba,Arnaud Agin,Rémy Sapin,Patrick Poulet,Blandine Guignard,Nathalie Parizel,Daniel Grucker,Nelly Boehm,Robert H. Miller,M. Said Ghandour +11 more
TL;DR: Injection of triiodothyronine (T3) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination, establishing a role for T3 as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelinations.
Journal ArticleDOI
Astrocytic hypertrophy in dysmyelination influences the diffusion anisotropy of white matter
Laura A. Harsan,Patrick Poulet,Blandine Guignard,Nathalie Parizel,Robert P. Skoff,M. Said Ghandour +5 more
TL;DR: The amplified magnitude of radial and axial diffusions in jimpy males was attributed principally to the strongly pronounced astrocyte hypertrophy, and major changes of DT‐MRI parameters in the two dysmyelinated mice caused by the myelin loss and axonal modifications were highlighted.
Journal ArticleDOI
Remyelination assessment by MRI texture analysis in a cuprizone mouse model
Olivier Yu,Jérôme Steibel,Y. Mauss,Blandine Guignard,Bernard Eclancher,Jacques Chambron,Daniel Grucker +6 more
TL;DR: The time evolution of the average value of HGLNU not only confirmed the overall demyelination tendency followed by the average intensity, but also characterized a transitory remyelinated on day 41 in the olfactory bulbs and cerebellum, in agreement with already published immunohistochemical destructive studies.