J
Jérôme Steibel
Researcher at Centre national de la recherche scientifique
Publications - 22
Citations - 740
Jérôme Steibel is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: In vivo & Oligodendrocyte. The author has an hindex of 11, co-authored 22 publications receiving 698 citations. Previous affiliations of Jérôme Steibel include Sirna Therapeutics.
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Journal ArticleDOI
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging.
Laura A. Harsan,Patrick Poulet,Blandine Guignard,Jérôme Steibel,Nathalie Parizel,Paulo Loureiro de Sousa,Nelly Boehm,Daniel Grucker,M. Said Ghandour +8 more
TL;DR: It is shown clearly that myelination and axonal changes play a role in the degree of diffusion anisotropy, because FA was significantly decreased in dysmyelinated brain.
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Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging
Laura A. Harsan,Jérôme Steibel,Anita Zaremba,Arnaud Agin,Rémy Sapin,Patrick Poulet,Blandine Guignard,Nathalie Parizel,Daniel Grucker,Nelly Boehm,Robert H. Miller,M. Said Ghandour +11 more
TL;DR: Injection of triiodothyronine (T3) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination, establishing a role for T3 as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelinations.
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Development of a Dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Contrast Agent : Synthesis, Toxicity (in Vitro) and Relaxivity (in Vitro, in Vivo) Studies
Annabelle Bertin,Jérôme Steibel,Anne-Isabelle Michou-Gallani,Jean-Louis Gallani,Delphine Felder-Flesch +4 more
TL;DR: Considering manganese(II) complex 1, the in vivo nontoxicity at 20 mM (100% rats survival) is very likely due to a slow diffusion of the compound, meaning a controlled release of the paramagnetic ions.
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Remyelination assessment by MRI texture analysis in a cuprizone mouse model
Olivier Yu,Jérôme Steibel,Y. Mauss,Blandine Guignard,Bernard Eclancher,Jacques Chambron,Daniel Grucker +6 more
TL;DR: The time evolution of the average value of HGLNU not only confirmed the overall demyelination tendency followed by the average intensity, but also characterized a transitory remyelinated on day 41 in the olfactory bulbs and cerebellum, in agreement with already published immunohistochemical destructive studies.
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In vivo dynamic MR imaging of MBP-induced acute experimental allergic encephalomyelitis in Lewis rat.
Izzie Jacques Namer,Jérôme Steibel,Patrick Poulet,Jean-Paul Armspach,Y. Mauss,Jacques Chambron +5 more
TL;DR: A dynamic in vivo study by MRI consisting of the measurement of relaxation times and in the visualization of the BBB permeability by Gd—DOTA establishes the essential role of BBB in the pathogenesis of clinical signs of this EAE model.