Bo Xu

TL;DR: Studying mouse models, it is demonstrated that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation and Clinically relevant Ezh2 inhibitors restore androgen receptor expression and sensitivity to antiandrogen therapy.

TL;DR: A thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients supports an important role for TfR 1 in R CC progression and identifies Tf R1 as a novel RCC biomarker and therapeutic target.

TL;DR: TAZ, a transcription co-activator and key downstream effector of the Hippo pathway, is identified as an essential driver for the propagation of TNBC malignant phenotype and pharmacological inhibition of TAZ activity may provide a novel means of targeting and eliminating breast CSCs.

TL;DR: It is hypothesized that elevated density of CD8+ TILs in the RP specimen would correlate with improved clinical outcomes, and this information may be helpful for future immunotherapy clinical trial design and treatment selection.

TL;DR: It is demonstrated that Sox4, one of the candidate oncogenes located within the chromosome 6p22 amplicon, confers bladder cancer stem cell (CSC) properties and may serve as a biomarker of the aggressive phenotype in bladder cancer.