J
Jianmin Wang
Researcher at Roswell Park Cancer Institute
Publications - 143
Citations - 10092
Jianmin Wang is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 37, co-authored 122 publications receiving 8064 citations. Previous affiliations of Jianmin Wang include St. Jude Children's Research Hospital & University at Buffalo.
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Journal ArticleDOI
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang,Li Ding,Linda Holmfeldt,Gang Wu,Susan L. Heatley,Susan L. Heatley,Debbie Payne-Turner,John Easton,Xiang Chen,Jianmin Wang,Michael Rusch,Charles Lu,Shann Ching Chen,Lei Wei,J. Racquel Collins-Underwood,Jing Ma,Kathryn G. Roberts,Stanley Pounds,Anatoly Ulyanov,Jared Becksfort,Pankaj Gupta,Robert Huether,Richard W. Kriwacki,Matthew Parker,Daniel J. McGoldrick,David Zhao,Daniel Alford,Stephen Espy,Kiran Chand Bobba,Guangchun Song,Deqing Pei,Cheng Cheng,Stefan Roberts,Michael I. Barbato,Michael I. Barbato,Dario Campana,Dario Campana,Elaine Coustan-Smith,Elaine Coustan-Smith,Sheila A. Shurtleff,Susana C. Raimondi,Maria Kleppe,Maria Kleppe,Jan Cools,Kristin A. Shimano,Michelle L. Hermiston,Sergei Doulatov,Kolja Eppert,Elisa Laurenti,Faiyaz Notta,John E. Dick,Giuseppe Basso,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,Brent L. Wood,Stuart S. Winter,Kimberley P. Dunsmore,Robert S. Fulton,Lucinda Fulton,Xin Hong,Chris Harris,David J. Dooling,Kerri Ochoa,Kimberly J. Johnson,John C. Obenauer,William E. Evans,Ching-Hon Pui,Clayton W. Naeve,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Charles G. Mullighan +73 more
TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Journal ArticleDOI
Novel mutations target distinct subgroups of medulloblastoma
Giles W. Robinson,Matthew Parker,Tanya A. Kranenburg,Charles Lu,Charles Lu,Xiang Chen,Li Ding,Li Ding,Timothy N. Phoenix,Erin Hedlund,Lei Wei,Xiaoyan Zhu,Nader Chalhoub,Suzanne J. Baker,Robert Huether,Richard W. Kriwacki,Natasha Curley,Radhika Thiruvenkatam,Jianmin Wang,Gang Wu,Michael Rusch,Xin Hong,Xin Hong,Jared Becksfort,Pankaj Gupta,Jing Ma,John Easton,Bhavin Vadodaria,Arzu Onar-Thomas,Tong Lin,Shaoyi Li,Stanley Pounds,Steven W. Paugh,David Zhao,Daisuke Kawauchi,Martine F. Roussel,David Finkelstein,David W. Ellison,Ching C. Lau,Eric Bouffet,Tim Hassall,Tim Hassall,Sridharan Gururangan,Sridharan Gururangan,Richard J. Cohn,Richard J. Cohn,Robert S. Fulton,Robert S. Fulton,Lucinda L. Fulton,Lucinda L. Fulton,David J. Dooling,David J. Dooling,Kerri Ochoa,Kerri Ochoa,Amar Gajjar,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Richard J. Gilbertson +59 more
TL;DR: Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumours identified genes that maintain this cell lineage (DDX3X), as well as mutated genes that initiate (CDH1) or cooperate (PIK3CA) in tumorigenesis.
Journal ArticleDOI
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Jinghui Zhang,Gang Wu,Claudia P. Miller,Ruth G. Tatevossian,James Dalton,Bo Tang,Wilda Orisme,Chandanamali Punchihewa,Matthew Parker,Ibrahim Qaddoumi,F.A. Boop,Charles Lu,Cyriac Kandoth,Li Ding,Ryan P. Lee,Robert Huether,Xiang Chen,Erin Hedlund,Panduka Nagahawatte,Michael Rusch,Kristy Boggs,Jinjun Cheng,Jared Becksfort,Jing Ma,Guangchun Song,Yongjin Li,Lei Wei,Jianmin Wang,Sheila A. Shurtleff,John Easton,David Zhao,Robert S. Fulton,Lucinda Fulton,David J. Dooling,Bhavin Vadodaria,Heather L. Mulder,Chunlao Tang,Kerri Ochoa,Charles G. Mullighan,Amar Gajjar,Richard W. Kriwacki,Denise Sheer,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Suzanne J. Baker,David W. Ellison +47 more
TL;DR: Focusing on the therapeutically challenging diffuse LGGs, this study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric L GGs and LGGNTs.
Journal ArticleDOI
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
Sheng-Yu Ku,Spencer Rosario,Yanqing Wang,Ping Mu,Mukund Seshadri,Zachary W. Goodrich,Maxwell M. Goodrich,David P. Labbé,Eduardo Cortes Gomez,Jianmin Wang,Henry W. Long,Bo Xu,Myles Brown,Massimo Loda,Charles L. Sawyers,Charles L. Sawyers,Leigh Ellis,David W. Goodrich +17 more
TL;DR: Studying mouse models, it is demonstrated that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation and Clinically relevant Ezh2 inhibitors restore androgen receptor expression and sensitivity to antiandrogen therapy.
Journal ArticleDOI
Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
Xiang Chen,Armita Bahrami,Alberto S. Pappo,John Easton,James T. Dalton,Erin Hedlund,David H. Ellison,Sheila A. Shurtleff,Gang Wu,Lei Wei,Matthew Parker,Michael Rusch,Panduka Nagahawatte,Jianrong Wu,Shenghua Mao,Kristy Boggs,Heather L. Mulder,Donald Yergeau,Charles Lu,Li Ding,Michael N. Edmonson,Chunxu Qu,Jianmin Wang,Yongjin Li,Fariba Navid,Najat C. Daw,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Michael A. Dyer +30 more
TL;DR: The authors performed whole-genome sequencing of DNA from 20 osteosarcoma tumor samples and matched normal tissue in a discovery cohort, as well as 14 samples in a validation cohort.