Boakye A. Boatin

TL;DR: The forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place are provided; the main obstacles that impede progress are identified; and recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections are discussed.

TL;DR: The results indicate that the significant microfilaridermias that persist despite multiple treatments with ivermectin are mainly attributable to the non-response of the adult female worms and not to inadequate drug exposure or other factors, and justify the routine monitoring of treatment efficacy in any iverMectin-based programme of disease control.

TL;DR: Emergence of FY*A(null) in this population suggests that P. vivax is involved in selection of this erythroid polymorphism, which would ultimately compromise alpha(+)-thalassemia/P.

TL;DR: Analysis of RANTES compound genotype frequencies between HIV-positive and exposed-uninfected participants of the Multicenter AIDS Cohort Study and rates of progression to AIDS for MACS seroconverters implicate the RantES-403A allele as a risk factor for HIV transmission and as a protective factor for AIDS progression.

TL;DR: To achieve the goals of morbidity reduction or elimination of infection, novel tools need to be developed, including more efficacious drugs, vaccines, and/or antivectorial agents, new diagnostics for infection and assessment of drug efficacy, and markers for possible anthelmintic resistance.