B
Boerries Brandenburg
Researcher at Janssen Pharmaceutica
Publications - 29
Citations - 3123
Boerries Brandenburg is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Hemagglutinin (influenza) & Influenza A virus. The author has an hindex of 17, co-authored 27 publications receiving 2740 citations. Previous affiliations of Boerries Brandenburg include Johnson & Johnson & Robert Koch Institute.
Papers
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Journal ArticleDOI
A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses
Damian C. Ekiert,Robert H. E. Friesen,Gira Bhabha,Ted Kwaks,Mandy Jongeneelen,Wenli Yu,C. Ophorst,Freek Cox,Hans J. W. M. Korse,Boerries Brandenburg,Ronald Vogels,Just P. J. Brakenhoff,Ronald Kompier,Martin H. Koldijk,Lisette A. H. M. Cornelissen,Leo L.M. Poon,Malik Peiris,Wouter Koudstaal,Ian A. Wilson,Jaap Goudsmit +19 more
TL;DR: The isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7, which cause severe human infection are reported.
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Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
Bo Huang,Sara A. Jones,Boerries Brandenburg,Boerries Brandenburg,Xiaowei Zhuang,Xiaowei Zhuang +5 more
TL;DR: Multicolor three-dimensional stochastic optical reconstruction microscopy (STORM) is demonstrated as a tool to quantitatively probe cellular structures and their interactions to enhance understanding of molecular processes in cells.
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Virus trafficking – learning from single-virus tracking
TL;DR: Single-virus tracking in living cells allows us to follow the fate of individual virus particles and monitor dynamic interactions between viruses and cellular structures, revealing previously unobservable infection steps.
Journal ArticleDOI
Imaging Poliovirus Entry in Live Cells
Boerries Brandenburg,Lily Y. Lee,Melike Lakadamyali,Michael J. Rust,Xiaowei Zhuang,Xiaowei Zhuang,James M. Hogle +6 more
TL;DR: Surprisingly, it is observed that genome release by PV is highly efficient and rapid, and thus does not limit the overall infectivity or the infection rate, and this imaging assay is broadly applicable to the investigation of entry mechanisms for nonenveloped viruses.
Journal ArticleDOI
Mechanisms of hemagglutinin targeted influenza virus neutralization.
Boerries Brandenburg,Wouter Koudstaal,Jaap Goudsmit,Vincent Klaren,Chan Tang,Miriam V. Bujny,Hans J. W. M. Korse,Ted Kwaks,Jason J. Otterstrom,Jarek Juraszek,Antoine M. van Oijen,Ronald Vogels,Robert H. E. Friesen +12 more
TL;DR: Insight into newly identified ways by which the human immune system can interfere with influenza virus infection may aid the development of novel universal vaccines and antivirals.