B
Bogdan F. Gh. Popescu
Researcher at University of Saskatchewan
Publications - 36
Citations - 3870
Bogdan F. Gh. Popescu is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Multiple sclerosis & Neuromyelitis optica. The author has an hindex of 23, co-authored 35 publications receiving 3266 citations. Previous affiliations of Bogdan F. Gh. Popescu include Stanford University & Saskatoon City Hospital.
Papers
More filters
Journal ArticleDOI
Inflammatory Cortical Demyelination in Early Multiple Sclerosis
Claudia F. Lucchinetti,Bogdan F. Gh. Popescu,Reem F. Bunyan,Natalia M. Moll,Shanu F. Roemer,Hans Lassmann,Wolfgang Brück,Joseph E. Parisi,Bernd W. Scheithauer,Caterina Giannini,Stephen D. Weigand,Jay Mandrekar,Richard M. Ransohoff +12 more
TL;DR: In this cohort of patients with early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and strongly associated with meningeal inflammation.
Journal ArticleDOI
Association between pathological and MRI findings in multiple sclerosis
Massimo Filippi,Maria A. Rocca,Frederik Barkhof,Wolfgang Brück,Jacqueline T. Chen,Giancarlo Comi,Gabriele C. DeLuca,Nicola De Stefano,Bradley J. Erickson,Nikos Evangelou,Franz Fazekas,Jeroen J. G. Geurts,Claudia F. Lucchinetti,David Miller,Daniel Pelletier,Bogdan F. Gh. Popescu,Hans Lassmann +16 more
TL;DR: A number of correlative pathological and MRI studies have helped to define in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also in the spinal cord.
Journal ArticleDOI
The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica.
Claudia F. Lucchinetti,Yong Guo,Bogdan F. Gh. Popescu,Bogdan F. Gh. Popescu,Kazuo Fujihara,Yasuto Itoyama,Tatsuro Misu +6 more
TL;DR: Neuromyelitis optica is a disabling autoimmune astrocytopathy characterized by typically severe and recurrent attacks of optic neuritis and longitudinally extensive myelitis and recent neuropathological studies provide novel insights into the pathogenic mechanisms, cellular targets, as well as the spectrum of tissue damage in NMO.
Journal ArticleDOI
Pathology of Demyelinating Diseases
TL;DR: The pathological features of these central nervous system inflammatory demyelinating disorders are reviewed and neuropathological studies that have yielded novel insights into potential mechanisms involved in the formation of the demYelinated lesion are discussed.
Journal ArticleDOI
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes
Shannon R. Hinson,Michael F. Romero,Bogdan F. Gh. Popescu,Claudia F. Lucchinetti,James P. Fryer,Hartwig Wolburg,Petra Fallier-Becker,Susan Noell,Vanda A. Lennon +8 more
TL;DR: Two previously unappreciated histopathological correlates supporting the clinical relevance of the in vitro findings of NMO-IgG are identified: reactive astrocytes with persistent foci of surface AQP4 and vacuolation in adjacent myelin consistent with edema.