J
Jacqueline T. Chen
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 20
Citations - 1373
Jacqueline T. Chen is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Multiple sclerosis & Magnetic resonance imaging. The author has an hindex of 9, co-authored 20 publications receiving 1093 citations. Previous affiliations of Jacqueline T. Chen include Montreal Neurological Institute and Hospital & McGill University.
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Journal ArticleDOI
Association between pathological and MRI findings in multiple sclerosis
Massimo Filippi,Maria A. Rocca,Frederik Barkhof,Wolfgang Brück,Jacqueline T. Chen,Giancarlo Comi,Gabriele C. DeLuca,Nicola De Stefano,Bradley J. Erickson,Nikos Evangelou,Franz Fazekas,Jeroen J. G. Geurts,Claudia F. Lucchinetti,David Miller,Daniel Pelletier,Bogdan F. Gh. Popescu,Hans Lassmann +16 more
TL;DR: A number of correlative pathological and MRI studies have helped to define in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also in the spinal cord.
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Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial
Harold L. Atkins,Harold L. Atkins,Harold L. Atkins,Marjorie Bowman,Marjorie Bowman,David S. Allan,David S. Allan,David S. Allan,Grizel Anstee,Douglas L. Arnold,Amit Bar-Or,Isabelle Bence-Bruckler,Isabelle Bence-Bruckler,Paul Birch,Christopher Bredeson,Christopher Bredeson,Christopher Bredeson,Jacqueline T. Chen,Jacqueline T. Chen,Dean Fergusson,Dean Fergusson,Mike Halpenny,Linda Hamelin,Lothar Huebsch,Lothar Huebsch,Brian Hutton,Pierre Laneuville,Yves Lapierre,Hyun-Woo Lee,Lisa Martin,Sheryl McDiarmid,Paul O'Connor,Tim Ramsay,Tim Ramsay,Mitchell Sabloff,Mitchell Sabloff,Lisa Walker,Lisa Walker,Mark S. Freedman,Mark S. Freedman,Mark S. Freedman +40 more
TL;DR: The first treatment to fully halt all detectable CNS inflammatory activity in patients with multiple sclerosis for a prolonged period in the absence of any ongoing disease-modifying drugs is described.
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Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
Zhihong Chen,Walid Jalabi,Weiwei Hu,Hyun Joo Park,John T. Gale,Grahame J. Kidd,Rodica Bernatowicz,Zachary C. Gossman,Jacqueline T. Chen,Ranjan Dutta,Bruce D. Trapp +10 more
TL;DR: 3D electron microscopy results indicate that activated microglia can protect the adult brain by migrating to inhibitory synapses and displacing them from cortical neurons.
Journal ArticleDOI
Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study
Bruce D. Trapp,Megan C. Vignos,Megan C. Vignos,Jessica Dudman,Ansi Chang,Elizabeth Fisher,Susan M. Staugaitis,Susan M. Staugaitis,Harsha Battapady,Sverre Mørk,Sverre Mørk,Daniel Ontaneda,Stephen E. Jones,Robert J. Fox,Jacqueline T. Chen,Kunio Nakamura,Richard A. Rudick +16 more
TL;DR: It is proposed that myelocortical multiple sclerosis is a subtype of multiple sclerosis that is characterised by demyelination of spinal cord and cerebral hemispheres but not of cerebral white matter.
Journal ArticleDOI
Clinically feasible MTR is sensitive to cortical demyelination in MS
Jacqueline T. Chen,Kathryn E. Easley,Colleen L. Schneider,Kunio Nakamura,Grahame J. Kidd,Ansi Chang,Susan M. Staugaitis,Robert J. Fox,Elizabeth M. C. Fisher,Douglas L. Arnold,Bruce D. Trapp +10 more
TL;DR: This result demonstrates that clinically feasible MTR imaging is sensitive to cortical demyelination and suggests that MTR will be a useful tool to help detect MS cortical lesions in living patients with MS.