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Boris Illarionov
Researcher at University of Hamburg
Publications - 102
Citations - 2303
Boris Illarionov is an academic researcher from University of Hamburg. The author has contributed to research in topics: Riboflavin synthase & Lumazine synthase. The author has an hindex of 26, co-authored 99 publications receiving 2076 citations. Previous affiliations of Boris Illarionov include Purdue University & Russian Academy.
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Book ChapterDOI
Biosynthesis of riboflavin.
Adelbert Bacher,Sabine Eberhardt,Wolfgang Eisenreich,Markus Fischer,Stefan Herz,Boris Illarionov,Klaus Kis,Gerald Richter +7 more
TL;DR: Two reaction steps in the biosynthetic pathway catalyzed by 3,4-dihydroxy-2-butanone 4-phosphate synthase and riboflavin synthase are mechanistically very complex.
Book ChapterDOI
Recombinant obelin: cloning and expression of cDNA purification, and characterization as a calcium indicator.
Boris Illarionov,Ludmila A. Frank,Victoria Illarionova,Vladimir S. Bondar,Eugene S. Vysotski,John R. Blinks +5 more
Journal ArticleDOI
Sequence of the cDNA encoding the Ca2+-activated photoprotein obelin from the hydroid polyp Obelia longissima ☆
TL;DR: The deduced amino acid sequence of apoObl revealed that this 195-aa protein has three EF-hand structures that are characteristic for Ca(2+)-binding domains, and strong aa homology was shown among apObl, apoaequorin and apoclytin.
Journal ArticleDOI
Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,)
Ekaterina Morgunova,Winfried Meining,Boris Illarionov,Ilka Haase,Guangyi Jin,Adelbert Bacher,Mark Cushman,Markus Fischer,Rudolf Ladenstein +8 more
TL;DR: The structure of lumazine synthase from M. tuberculosis in complex with two purinetrione inhibitors is determined and the impact of structural changes in the active site on the altered binding and catalytic properties of the enzyme is discussed.
Journal ArticleDOI
Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
Julie G. Geist,Susan Lauw,Victoria Illarionova,Boris Illarionov,Markus Fischer,Tobias Gräwert,Felix Rohdich,Wolfgang Eisenreich,Johannes Kaiser,Michael Groll,Christian Scheurer,Sergio Wittlin,José L. Alonso-Gómez,W. Bernd Schweizer,Adelbert Bacher,François Diederich +15 more
TL;DR: A thiazolopyrimidine derivative resulting from the high‐throughput screen was found to inhibit the IspF proteins of Mycobacterium tuberculosis, Plasmodium falciparum, and A. thaliana with IC50 values in the micromolar range.