C
Christian Scheurer
Researcher at Swiss Tropical and Public Health Institute
Publications - 21
Citations - 1716
Christian Scheurer is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Plasmodium falciparum & Arterolane. The author has an hindex of 14, co-authored 20 publications receiving 1580 citations. Previous affiliations of Christian Scheurer include University of Nebraska Medical Center & University of Basel.
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Journal ArticleDOI
Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
Susan A. Charman,Sarah Arbe-Barnes,Ian Bathurst,Reto Brun,Michael Campbell,William N. Charman,Francis C. K. Chiu,Jacques Chollet,J. Carl Craft,Darren J. Creek,Yuxiang Dong,Hugues Matile,Melanie Maurer,Julia Morizzi,Tien Nguyen,Petros Papastogiannidis,Christian Scheurer,David M. Shackleford,Kamaraj Sriraghavan,Lukas Stingelin,Yuanqing Tang,Heinrich Urwyler,Xiaofang Wang,Karen L. White,Sergio Wittlin,Lin Zhou,Jonathan L. Vennerstrom +26 more
TL;DR: The outstanding efficacy and prolonged blood concentrations of OZ439 are the result of a design strategy that stabilizes the intrinsically unstable pharmacophoric peroxide bond, thereby reducing clearance yet maintaining the necessary Fe(II)-reactivity to elicit parasite death.
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Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Yuxiang Dong,Jacques Chollet,Hugues Matile,Susan A. Charman,Francis C. K. Chiu,William N. Charman,Bernard Scorneaux,Heinrich Urwyler,Josefina Santo Tomas,Christian Scheurer,Christopher Snyder,Arnulf Dorn,Xiaofang Wang,Jean M. Karle,Yuanqing Tang,Sergio Wittlin,Reto Brun,Jonathan L. Vennerstrom +17 more
TL;DR: The trioxolanes were substantially less effective in a standard oral suspension formulation compared to a solubilizing formulation and were more active when administered subcutaneously than orally, both of which suggest substantial biopharmaceutical liabilities.
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In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
TL;DR: In vitro and in vivo activities of piperaquine in combination with RBx11160 and artemether demonstrated a slight tendency towards antagonism, suggesting that a RBx 11160-piperquine combination therapy in humans should allow each molecule to exert its full antimalarial effect.
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The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Yuxiang Dong,Sergio Wittlin,Kamaraj Sriraghavan,Jacques Chollet,Susan A. Charman,William N. Charman,Christian Scheurer,Heinrich Urwyler,Josefina Santo Tomas,Christopher Snyder,Darren J. Creek,Julia Morizzi,Maria Koltun,Hugues Matile,Xiaofang Wang,Maniyan Padmanilayam,Yuanqing Tang,Arnulf Dorn,Reto Brun,Jonathan L. Vennerstrom +19 more
TL;DR: Five new ozonides with antimalarial efficacy and ADME profiles superior or equal to that of arterolane were identified.