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Boris Mravec
Researcher at Comenius University in Bratislava
Publications - 126
Citations - 1921
Boris Mravec is an academic researcher from Comenius University in Bratislava. The author has contributed to research in topics: Cancer & Catecholamine. The author has an hindex of 22, co-authored 118 publications receiving 1558 citations. Previous affiliations of Boris Mravec include Slovak Academy of Sciences.
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Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario
Cestmir Altaner,Veronika Altanerova,Marina Cihova,Katarina Ondicova,Boris Rychly,Ladislav Baciak,Boris Mravec,Boris Mravec +7 more
TL;DR: Evaluated therapeutic efficacy of human mesenchymal stem cells derived from bone marrow and from adipose tissue, engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracerebral rat C6 glioblastoma found to be therapeutically efficient.
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Human adipose tissue‐derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma
Veronika Altanerova,Marina Cihova,Michal Babič,Boris Rychly,Katarina Ondicova,Boris Mravec,Boris Mravec,Cestmir Altaner +7 more
TL;DR: It is demonstrated that genetically modified therapeutic stem cells still have the tumor tropism when injected to a distant intracranial site and effectively inhibited glioblastoma growth after 5‐fluorocytosine (5‐FC) therapy.
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Role of nervous system in cancer aetiopathogenesis
TL;DR: A neurobiological view of cancer aetiopathogenesis suggests that humoral and nervous pathways convey signals from tumour cells to the brain, and that the brain might consequently modulate the neuroendocrine-immune system to regulate tumour growth in peripheral tissues.
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You may need the vagus nerve to understand pathophysiology and to treat diseases.
TL;DR: Evidence is provided for the hypothesis that adequate vagal nerve activity reduces the risk of major diseases, via common basic mechanisms and interim risk factors, and vagal activity is proposed to moderate the effects of risk factors on developing such illnesses.
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Intracerebroventricular oxytocin administration in rats enhances object recognition and increases expression of neurotrophins, microtubule‐associated protein 2, and synapsin I
Tomas Havranek,Martina Zatkova,Zuzana Lestanova,Zuzana Bacova,Zuzana Bacova,Boris Mravec,Boris Mravec,Július Hodosy,Vladimír Štrbák,Vladimír Štrbák,Jan Bakos,Jan Bakos +11 more
TL;DR: The results provide the first direct evidence implicating oxytocin as a regulator of brain plasticity at the level of changes of neuronal growth factors, cytoskeletal proteins, and behavior and support assumption that Oxytocin is important for short‐term hippocampus‐dependent memory.