Boris Zacchetti

TL;DR: Correlating qS and qP is of utmost importance for bioprocess observability and control and can be modeled actually by advanced metabolic flux models, but if most of these models are able to make prediction about metabolic switches still do not incorporate deviation due to biological noise, i.e. phenotypic and genotypic heterogeneity.

TL;DR: The results show that Raman spectroscopy delivers the necessary resolution to quantify phenotypic diversity within individual cells and that this information can be used to study stress-driven metabolic diversity in microbial populations.

TL;DR: This work has been focused on the induction of the arabinose operon in Escherichia coli as a model system, and suggests that constraining individual cells into a given phenotypic trajectory is maybe not the best strategy for directing cell population.

TL;DR: In this paper, the authors focused on the induction of the arabinose operon in Escherichia coli as a model system, using flow cytometry in chemostat with glucose-arabinose co-feeding.

TL;DR: This work has been focused on the induction of the arabinose operon in Escherichia coli as a model system, and suggests that constraining individual cells into a given phenotypic trajectory is maybe not the best strategy for directing cell population.