B
Borys Zimenkovsky
Researcher at Danylo Halytsky Lviv National Medical University
Publications - 58
Citations - 1835
Borys Zimenkovsky is an academic researcher from Danylo Halytsky Lviv National Medical University. The author has contributed to research in topics: Thiazole & Pyrazoline. The author has an hindex of 19, co-authored 55 publications receiving 1603 citations.
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Journal ArticleDOI
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
Dmytro Havrylyuk,Borys Zimenkovsky,Olexandr Vasylenko,Lucjusz Zaprutko,Andrzej Gzella,Roman Lesyk +5 more
TL;DR: The most efficient anticancer compound 16 was found to be active with selective influence on colon cancer cell lines, especially on HT 29 (logGI(50)=-6.37) and in vitro anticancer activity of synthesized compounds were tested by the National Cancer Institute.
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Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
Dmytro Havrylyuk,Ludmyla Mosula,Borys Zimenkovsky,Olexandr Vasylenko,Andrzej Gzella,Roman Lesyk +5 more
TL;DR: In vitro anticancer activity of the synthesized compounds was tested by the National Cancer Institute and two of them has revealed the antic cancer activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.
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Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity.
Dmytro Havrylyuk,Borys Zimenkovsky,Olexandr Vasylenko,Andrzej Gzella,Andrzej Gzella,Roman Lesyk +5 more
TL;DR: The most effective anticancer compound 10 was found to be active with mean GI₅₀ and TGI values of 0.071 μM and 0.76 μM, respectively and demonstrated the highest antiproliferative influence on the non-small-cell lung cancer cell line HOP-92.
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Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.
Roman Lesyk,Borys Zimenkovsky,Dmytro Atamanyuk,Dmytro Atamanyuk,Frank Jensen,Katarzyna Kieć-Kononowicz,Andrzej Gzella +6 more
TL;DR: The lipophilicity of the compounds was studied by RP-TLC and found to correlate well with calculated logP values, and high correlations with some of the antitubulin agents were showed.
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Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates
TL;DR: Five novel isatin based conjugates with thiazolidine and pyrazoline moieties were synthesized and found to be the most active candidate with selective influence on leukemia subpanel tumor cell lines with GI50 values range of 0.69–3.35 µM.