Olexandr Vasylenko

TL;DR: The most efficient anticancer compound 16 was found to be active with selective influence on colon cancer cell lines, especially on HT 29 (logGI(50)=-6.37) and in vitro anticancer activity of synthesized compounds were tested by the National Cancer Institute.

TL;DR: In vitro anticancer activity of the synthesized compounds was tested by the National Cancer Institute and two of them has revealed the antic cancer activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.

TL;DR: The most effective anticancer compound 10 was found to be active with mean GI₅₀ and TGI values of 0.071 μM and 0.76 μM, respectively and demonstrated the highest antiproliferative influence on the non-small-cell lung cancer cell line HOP-92.

TL;DR: Five novel isatin based conjugates with thiazolidine and pyrazoline moieties were synthesized and found to be the most active candidate with selective influence on leukemia subpanel tumor cell lines with GI50 values range of 0.69–3.35 µM.

TL;DR: Series of novel 5-arylidene-2-arylaminothiazol-4(5H)-ones and 2-aryl(benzyl)amino-1H-imidazol- 4(5h)-ones were synthesized from appropriate 2-alkylthioazols using nucleophilic substitution in position 2 by various anilines and benzylamines and Knoevenagel reaction to disclose probable modes of anticancer action.