Journal ArticleDOI
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.
Dmytro Havrylyuk,Borys Zimenkovsky,Olexandr Vasylenko,Lucjusz Zaprutko,Andrzej Gzella,Roman Lesyk +5 more
TLDR
The most efficient anticancer compound 16 was found to be active with selective influence on colon cancer cell lines, especially on HT 29 (logGI(50)=-6.37) and in vitro anticancer activity of synthesized compounds were tested by the National Cancer Institute.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2009-04-01. It has received 246 citations till now. The article focuses on the topics: Pyrazoline.read more
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4-Thiazolidinones: the advances continue….
Avinash C. Tripathi,Shiv Gupta,Gul Naz Fatima,Pankaj Kumar Sonar,Amit Verma,Shailendra K. Saraf +5 more
TL;DR: The last section of the review encompasses the various patents granted on 4-thiazolidinone analogs/derivatives with World Intellectual Proprietary Organization and United State Patent Trademark Office (USPTO), particularly in the duration of the year 2000 to the year 2012.
Journal ArticleDOI
Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
Dmytro Havrylyuk,Ludmyla Mosula,Borys Zimenkovsky,Olexandr Vasylenko,Andrzej Gzella,Roman Lesyk +5 more
TL;DR: In vitro anticancer activity of the synthesized compounds was tested by the National Cancer Institute and two of them has revealed the antic cancer activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.
Journal ArticleDOI
Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity.
Dmytro Havrylyuk,Borys Zimenkovsky,Olexandr Vasylenko,Andrzej Gzella,Andrzej Gzella,Roman Lesyk +5 more
TL;DR: The most effective anticancer compound 10 was found to be active with mean GI₅₀ and TGI values of 0.071 μM and 0.76 μM, respectively and demonstrated the highest antiproliferative influence on the non-small-cell lung cancer cell line HOP-92.
Journal ArticleDOI
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
TL;DR: Results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment and have a great potential and significance for further investigations.
Journal ArticleDOI
Thiazole-containing compounds as therapeutic targets for cancer therapy.
TL;DR: This review presents current research on thiazoles and elucidates their biological importance in anticancer drug discovery and the findings may aid researchers in the rational design of more potent and bio-target specific antic cancer drug molecules.
References
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ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI)
TL;DR: L Lists of software presented and~or reviewed in the Journal of Applied Crystallography are available on the World Wide Web at the above address, together with information about the availability of the software where this is known.
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WinGX suite for small-molecule single-crystal crystallography
TL;DR: The category Computer Program Abstracts provides a rapid means of communicating up-to-date information concerning both new programs or systems and signi®cant updates to existing ones.
Journal ArticleDOI
General definition of ring puckering coordinates
Dieter Cremer,John A. Pople +1 more
TL;DR: In this article, a unique mean plane is defined for a general monocyclic puckered ring, which is described by amplitude and phase coordinates which are generalizations of those introduced for cyclopentane by Kilpatrick, Pitzer, and Spitzer.
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Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
Anne Monks,Dominic A. Scudiero,Philip Skehan,Robert H. Shoemaker,Kenneth D. Paull,David T. Vistica,Curtis Hose,John Langley,Paul Cronise,Anne Vaigro-Wolff,Marcia Gray-Goodrich,H. D. Campbell,Joseph G. Mayo,Michael R. Boyd +13 more
TL;DR: A pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60 human tumor cell lines organized into subpanels representing leukemia, melanoma, and cancers of the lung, colon, kidney, ovary, and central nervous system is described.
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Some Practical Considerations and Applications of the National Cancer Institute In Vitro Anticancer Drug Discovery Screen
Michael R. Boyd,Kenneth D. Paull +1 more
TL;DR: Practical considerations and selected specific examples are selected, particularly illustrating research applications of the NCI screen that may be more broadly applicable to the search for new anticancer drug development leads with novel profiles of antitumor activity and/or mechanisms of action.