Boyd Hardesty

TL;DR: The papers in this book cover the Ribosome conference held at the University of Texas Marine Science Institute and topics covered include: Structure of ribosomes; Self-organization ofribosomal RNA; Structural dynamics of the translating ribosome; and Mechanism of Ribosomes Translocation.

TL;DR: Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent movement, and release of transfer RNA from the donor site of reticulocyte ribosomes, as well as both the initiation and extension of globin and phenylalanine peptides.

TL;DR: Observations of the rate of amino acid incorporation indicate a sodium fluoride-sensitive reaction related to the initiation of new peptide chains on ribosomes that may bring about the increase in the proportion of monomeric ribosome because of a failure to re-form polysomes.

TL;DR: Highly purified preparations of hemin-controlled repressor of rabbit reticulocyte contain a 3':5'-cyclic AMP-indenpendent protein kinase activity that phosphorylates the low-molecular-weight polypeptide chain of the initiation factor that forms a ternary complex with GTP and Met-tRNAf.

TL;DR: Cycloheximide blocks the movement of peptidyl-tRNA from acceptor (aminoacyl) site to the donor (peptidyl) site on reticulocyte ribosomes and has no effect on the ribosome dependent GTPase activity of TF-II or on the peptide transferase reaction by which peptides on tRNA in the donor ribosomal site are transferred to an amino acid on t RNA in the acceptor site.