J
John F. Fallon
Researcher at University of Wisconsin-Madison
Publications - 106
Citations - 7917
John F. Fallon is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Limb development & Limb bud. The author has an hindex of 46, co-authored 106 publications receiving 7742 citations. Previous affiliations of John F. Fallon include Nagoya University & University of New Mexico.
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Journal ArticleDOI
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
TL;DR: It is demonstrated that PKA-dependent processing of vertebrate Gli3 in developing limb similarly generates a potent repressor in a manner antagonized by apparent long-range signaling from posteriorly localized Sonic hedgehog protein.
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Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
TL;DR: It is proposed that the function of Shh and Gli3 in limb skeletal patterning is limited to refining autopodial morphology, imposing pentadactyl constraint on the limb's polydactyl potential, and organizing digit identity specification, by regulating the relative balance of Gli 3 transcriptional activator and repressor activities.
Journal ArticleDOI
FGF-2: apical ectodermal ridge growth signal for chick limb development
TL;DR: Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development.
Book ChapterDOI
Fibroblast growth factors as multifunctional signaling factors.
Györgyi Szebenyi,John F. Fallon +1 more
TL;DR: The fibroblast growth factor (FGF) family consists of at least 15 structurally related polypeptide growth factors that influence the formation of the primary body axis, neural axis, limbs, and other structures through effects on gene expression and the cytoskeleton.
Journal ArticleDOI
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
Chin Chiang,Ying Litingtung,Matthew P. Harris,B. Kay Simandl,Yina Li,Philip A. Beachy,John F. Fallon +6 more
TL;DR: According to this model, the limb bud signaling centers, including the zone of polarizing activity (ZPA) acting through Shh, are required to elaborate upon the axial information provided by the native limb field prepattern to form autopodial structures in the mutant.