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Bradley Dean Tait
Researcher at Parke-Davis
Publications - 31
Citations - 1351
Bradley Dean Tait is an academic researcher from Parke-Davis. The author has contributed to research in topics: Protease & HIV Protease Inhibitor. The author has an hindex of 14, co-authored 31 publications receiving 1325 citations. Previous affiliations of Bradley Dean Tait include Louisiana State University.
Papers
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Book ChapterDOI
Nonpeptide inhibitors of HIV protease
TL;DR: A combination of good antiviral efficacy, good pharmacokinetics, and low P450 inhibition make PD 178390 a promising agent for the treatment of HIV infection.
Journal ArticleDOI
Discovery and optimization of nonpeptide HIV-1 protease inhibitors
Peter J. Tummino,J. V. N. Vara Prasad,Donna Ferguson,Carolyn Nouhan,Neil Graham,John M. Domagala,Edmund L. Ellsworth,Christopher Gajda,Susan Elizabeth Hagen,Elizabeth A. Lunney,Kimberly Suzanne Para,Bradley Dean Tait,Alexander Pavlovsky,John W. Erickson,Stephen J. Gracheck,Thomas J. McQuade,Donald Hupe +16 more
TL;DR: The value of the HIV-1 protease inhibitors described is their potential as better pharmacological agents with a different pattern of viral resistance development, relative to the peptide inhibitors in human clinical trials.
Patent
Pyrone derivatives as protease inhibitors and antiviral agents
John M. Domagala,Edmund L. Ellsworth,Elizabeth A. Lunney,Daniel F. Ortwine,Kimberly Suzanne Para,Josyula Vara Prasad,Tomi K. Sawyer,Bradley Dean Tait +7 more
TL;DR: The tri-and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS as discussed by the authors.
Journal ArticleDOI
Competitive Inhibition of HIV-1 Protease by Biphenyl Carboxylic Acids
Peter J. Tummino,D. Ferguson,C.M. Jacobs,Bradley Dean Tait,L. Hupe,Elizabeth A. Lunney,D. Hupe +6 more
TL;DR: Molecular modeling has provided information on a possible binding mode for two different biphenyl carboxylic acid inhibitors of HIV-1 protease, and the slow-binding inhibitor is the most potent in the series.
Patent
Amino acid analogs as CCK antagonists
David Christopher Horwell,Julian Aranda,Corinne E. Augelli-Szafran,Hans-Jurgen Betche,Ann Holmes,Michael David Mullican,Martyn Clive Pritchard,Reginald Stewart Richardson,Bruce David Roth,Edward Roberts,Bradley Dean Tait,Bharat Kalidas Trivedi,Uwe Trostmann,Paul C. Unangst +13 more
TL;DR: Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed.