D
Donald Hupe
Researcher at Pfizer
Publications - 61
Citations - 2033
Donald Hupe is an academic researcher from Pfizer. The author has contributed to research in topics: Matrix metalloproteinase & Protease. The author has an hindex of 28, co-authored 61 publications receiving 1961 citations. Previous affiliations of Donald Hupe include Parke-Davis & University of Texas at Dallas.
Papers
More filters
Journal ArticleDOI
Pharmaceutical Design and Development. A Molecular Biology Approach Edited by T. V. Ramabhadran (Neurogen Corp.). Ellis Horwood: New Jersey. 1994. viii + 337 pp. ISBN 0-13-553884-X.
Journal ArticleDOI
Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
J. V. N. Vara Prasad,Kimberly Suzanne Para,Elizabeth A. Lunney,Daniel F. Ortwine,James B. Dunbar,Donna Ferguson,Peter J. Tummino,Donald Hupe,Bradley Dean Tait +8 more
Journal ArticleDOI
X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
V. Dhanaraj,Ye Qi-Zhuang,Johnson Linda Lea,Donald Hupe,Daniel F. Ortwine,James B. Dunbar,J. R. Rubin,Alexander Pavlovsky,Christine Humblet,Tom L. Blundell +9 more
TL;DR: Structural comparisons of SCD with representative members of the metalloproteinase superfamily clearly highlight the conservation of key secondary structural elements, in spite of major variations in the sequences including insertions and deletions of functional domains.
Journal ArticleDOI
Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli.
TL;DR: Human stromelysin catalytic domain lacking both propeptide and C-terminal fragment provides an opportunity to elucidate the structure as well as the mechanism of catalysis and inhibition for matrix metalloproteinases.
Journal ArticleDOI
The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity
Peter J. Tummino,Jeffrey D. Scholten,Patricia J. Harvey,Tod P. Holler,Lisa Maloney,Rocco D. Gogliotti,John M. Domagala,Donald Hupe +7 more
TL;DR: Anti-HIV disulfide benzamides specifically eject NCp7 zinc and abolish the protein's ability to bind psi RNA in vitro, providing evidence for a possible antiretroviral mechanism of action of these compounds.