P
Peter J. Tummino
Researcher at Parke-Davis
Publications - 21
Citations - 661
Peter J. Tummino is an academic researcher from Parke-Davis. The author has contributed to research in topics: Protease & HIV-1 protease. The author has an hindex of 12, co-authored 21 publications receiving 645 citations. Previous affiliations of Peter J. Tummino include Pfizer.
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Journal ArticleDOI
Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
J. V. N. Vara Prasad,Kimberly Suzanne Para,Elizabeth A. Lunney,Daniel F. Ortwine,James B. Dunbar,Donna Ferguson,Peter J. Tummino,Donald Hupe,Bradley Dean Tait +8 more
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The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity
Peter J. Tummino,Jeffrey D. Scholten,Patricia J. Harvey,Tod P. Holler,Lisa Maloney,Rocco D. Gogliotti,John M. Domagala,Donald Hupe +7 more
TL;DR: Anti-HIV disulfide benzamides specifically eject NCp7 zinc and abolish the protein's ability to bind psi RNA in vitro, providing evidence for a possible antiretroviral mechanism of action of these compounds.
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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
Susan Elizabeth Hagen,J. V. N. Vara Prasad,Frederick E. Boyer,John M. Domagala,Edmund L. Ellsworth,Christopher Gajda,Harriet W. Hamilton,Larry J. Markoski,B. A. Steinbaugh,Bradley Dean Tait,Elizabeth A. Lunney,Peter J. Tummino,Donna Ferguson,Donald Hupe,Carolyn Nouhan,Stephen J. Gracheck,James Saunders,Steven VanderRoest +17 more
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The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities.
Peter J. Tummino,Patricia J. Harvey,Thomas J. McQuade,John M. Domagala,Rocco D. Gogliotti,Joseph P. Sanchez,Yuntao Song,Donald Hupe +7 more
TL;DR: The relative rates of HIV inactivation by various disulfide benzamides and benzisothiazolones correlate with their relative kinetic rates of NCp7 zinc ejection, which is consistent with the nucleocapsid protein being the target of action of these compounds.
Journal ArticleDOI
4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.
Bradley Dean Tait,Susan Elizabeth Hagen,John M. Domagala,Edmund L. Ellsworth,Christopher Gajda,Harriet W. Hamilton,J. V. N. Vara Prasad,Donna Ferguson,Neil Graham,Donald Hupe,Carolyn Nouhan,Peter J. Tummino,Christine Humblet,Elizabeth A. Lunney,Alexander Pavlovsky,J. R. Rubin,Stephen J. Gracheck,Eric T. Baldwin,T. N. Bhat,John W. Erickson,and Sergei V. Gulnik,Beishan Liu +21 more
TL;DR: The model led to the synthesis of 6,6-disubstituted dihydropyrones with the aim of filling S1 and S2 and thereby increasing the potency of the parent dihydropyrone 1c which did not fill S2.