Bradley M Keegan

TL;DR: It is determined that agonist-mediated reduction of the density of cell surface endogenously expressed CB1Rs was clathrin and dynamin dependent and could be modeled as agonists-induced aggregation of transiently expressed GFP-CB1R.

TL;DR: Modulation of Hsp90 by small molecules represents an attractive therapeutic approach against both peripheral and central neuropathies and can be counterbalanced by activation of the HSR.

TL;DR: A unique approach that enables the derivation and analysis of interactions between ligands and proteins from molecular dynamics trajectories was used to derive pharmacophore models for virtual screening (VS) and identify suitable binding sites for SB design.

TL;DR: The tools and assays summarized in this review should be used to develop Hsp90-targeting drugs with high specificity, potency, and drug-like properties that may prove immensely useful in the clinic.

TL;DR: It is postulate that those neuroadaptive effects of GABAB stimulation mediated by G-proteins and their sequelae correlate with tolerance to several of baclofen's effects, whereas sustained signaling via kinase cascades points to cross-talk between GABAB receptors and alternative mechanisms that are resistant to desensitization.