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Brás H. de Oliveira

Researcher at Federal University of Paraná

Publications -  35
Citations -  890

Brás H. de Oliveira is an academic researcher from Federal University of Paraná. The author has contributed to research in topics: Betulinic acid & Steviol. The author has an hindex of 18, co-authored 33 publications receiving 810 citations.

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Pharmacological Evaluation of Ricinine, a Central Nervous System Stimulant Isolated from Ricinus communis

TL;DR: The extract of the pericarp of castor bean showed some typical central nervous system stimulant effects when administered to mice, but at lower doses the extract improved memory consolidation and showed some neuroleptic-like properties, such as a decrease in exploratory behavior and catalepsy.
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Effects of Fish Oil on the Central Nervous System: A New Potential Antidepressant?

TL;DR: It is concluded that lifelong intake of FO was able to induce an antidepressant effect with EPA and DHA concentration increased in the cerebral cortex and hippocampus.
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Biotransformation of betulinic and betulonic acids by fungi.

TL;DR: F fungi isolated from the bark of Platanus orientalis as well as with Colletotrichum, obtained from corn leaves, converted betulinic acid into betulonic acid and are useful for mild, selective oxidations of lupane substrates at positions C-3,C-7, C-15, C -25 and C-30.
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Gibberellic acid production by solid-state fermentation in coffee husk

TL;DR: The comparative production of GA3 by solid-state fermentation and submerged fermentation indicated better productivity with the former technique, mainly with pretreated substrate, and higher yields ofGA3 were achieved using a mixed substrate comprising coffee husk and cassava bagasse, increasing the results twice.
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Preparation of betulinic acid derivatives by chemical and biotransformation methods and determination of cytotoxicity against selected cancer cell lines

TL;DR: The most selective, 3-hydroxy-20-[(2,4-dinitrophenyl)hydrazono]-29-norlupan-28-oic acid, was five to seven times more selective for cancer cells when compared to fibroblasts, and cell cycle analysis and apoptosis induction were studied.