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Brendan Crowley
Researcher at University College Dublin
Publications - 31
Citations - 833
Brendan Crowley is an academic researcher from University College Dublin. The author has contributed to research in topics: Population & Neisseria gonorrhoeae. The author has an hindex of 15, co-authored 31 publications receiving 717 citations.
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Journal ArticleDOI
Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey.
Simon R. Harris,Michelle J Cole,Gianfranco Spiteri,Leonor Sánchez-Busó,Daniel Golparian,Susanne Jacobsson,Richard Goater,Khalil Abudahab,Corin Yeats,Béatrice Berçot,Maria José Borrego,Brendan Crowley,Paola Stefanelli,Francesco Tripodo,Raquel Abad,David M. Aanensen,David M. Aanensen,Magnus Unemo,Jacinta Azevedo,Eszter Balla,Christopher Barbara,Thea Bergheim,Viviane Bremer,Susanne Buder,Panayiota Maikanti-Charalambous,Stephanie A. Chisholm,Susan Cowan,Tania Crucitti,Mercedes Diez,Maria Dudas,Kirstine Eastick,Agathe Goubard,Maria Haller,Guôrún Svanborg Hauksdóttir,Steen Hoffmann,Gwenda Hughes,Derval Igoe,Samo Jeverica,Irena Klavs,Hilde Kløvstad,Peter Kohl,Vasileia Konte,Ineke Linde,Violeta Mavcutko,Jackie M. Melillo,Gatis Pakarna,Peter Pavlik,Despo Pieridou,Guy La Ruche,Guôrún Sigmundsdóttir,Soteroulla Soteriou,Angelika Stary,Barbara Suligoi,Peter Truska,Eva Tzelepi,Birgit Van Benthem,Alje P. van Dam,Julio A. Vázquez,Inga Velicko,Ruth Verbrugge +59 more
TL;DR: This work provides the first use of joint analysis of WGS and epidemiological data in an international programme for regional surveillance of sexually transmitted infections and provides a framework for genomic surveillance of gonococci through standardised sampling, use of W GS, and a shared information architecture for interpretation and dissemination.
Journal ArticleDOI
WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014
Susanne Jacobsson,Daniel Golparian,Michelle J Cole,Gianfranco Spiteri,Irene Martin,Thea Bergheim,Maria José Borrego,Brendan Crowley,Tania Crucitti,Alje P. van Dam,Steen Hoffmann,Samo Jeverica,Peter Kohl,Beata Młynarczyk-Bonikowska,Gatis Pakarna,Angelika Stary,Paola Stefanelli,Peter Pavlik,Eva Tzelepi,Raquel Abad,Simon R. Harris,Magnus Unemo +21 more
TL;DR: The main azithromycin resistance mechanisms were the A2059G mutation (high-level resistance) and the C2611T mutation (low- and moderate- level resistance) in the 23S rRNA gene.
Journal ArticleDOI
Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.
Daniel Golparian,Lisa Rose,Almida Lynam,Aia Mohamed,Béatrice Berçot,Makoto Ohnishi,Brendan Crowley,Magnus Unemo +7 more
TL;DR: W Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015.
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Identification of a genomic subgroup of BK polyomavirus spread in European populations.
Hiroshi Ikegaya,Pekka Saukko,Risto Tertti,Kaj Metsärinne,Michael J. Carr,Brendan Crowley,Koichi Sakurada,Huai-Ying Zheng,Tadaichi Kitamura,Yoshiaki Yogo +9 more
TL;DR: A phylogenetic analysis based on complete BKV DNA sequences supported the hypothesis that there is geographical separation of European and Asian BKVs, and suggested that subgroup Ib-2 is widespread among Europeans, whereas Ic is unique to north-east Asians.
Journal ArticleDOI
Unique BK virus non-coding control region (NCCR) variants in hematopoietic stem cell transplant recipients with and without hemorrhagic cystitis.
TL;DR: Five previously unrecognized naturally occurring variants of the BKV are described which involve amplifications, deletions, and rearrangements of the archetypal BkV NCCRs in individuals with and without hemorrhagic cystitis.