Brendan Gilmore

TL;DR: In a helium-operated plasma jet, adding oxygen to the feed gas resulted in higher rates of DNA DSB, which increased linearly with increasing oxygen content, up to an optimum level of 0.75% oxygen, after which the DSB rate decreased slightly, indicating an essential role for reactive oxygen species in the rapid degradation of DNA.

TL;DR: This review examines recent innovations in synthetic substrates and protease-labelling with affinity-binding probes (or activity-based probes) as the field moves towards developing tools that could ultimately be used in patients for diagnostic or prognostic applications.

TL;DR: The potential of ultrashort tetra‐peptide conjugated to hydrophobic cinnamic acid derivatives to demonstrate selective and highly potent activity against resistant biofilm forms of Gram‐positive medical device‐related pathogens is highlighted.

TL;DR: Ad2-TAm exhibits an ability to convert a range of structurally diverse aldehyde and ketone substrates, with no decrease in conversion up to 1.5 M (8.8%) NaCl, making it a promising candidate for industrial applications, whilst also highlighting the value of extreme environments as a source of novel enzymes for the pharmaceutical industry as a whole.

TL;DR: The isolation of the first haloarchaeal TAm (BC61-TAm) to be characterised for the purposes of pharmaceutical biocatalysis is reported, representing an exciting advance in the study of transaminases from extremophiles, providing a possible scaffold for future discovery ofBiocatalytic enzymes with robust properties.