B
Brendan P. Cormack
Researcher at Johns Hopkins University
Publications - 19
Citations - 2199
Brendan P. Cormack is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Candida glabrata & Fungal protein. The author has an hindex of 17, co-authored 19 publications receiving 2033 citations. Previous affiliations of Brendan P. Cormack include Johns Hopkins University School of Medicine & Harvard University.
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Journal ArticleDOI
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.
Brendan P. Cormack,Kevin Struhl +1 more
TL;DR: Observations suggest that TBP is required for transcription of all nuclearly encoded genes in yeast, although distinct molecular mechanisms are probably involved for the three RNA polymerase transcription machineries.
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A nuclear receptor-like pathway regulating multidrug resistance in fungi
Jitendra K. Thakur,Haribabu Arthanari,Fajun Yang,Shih Jung Pan,Xiaochun Fan,Julia Breger,Dominique P. Frueh,Kailash Gulshan,Darrick K. Li,Eleftherios Mylonakis,Kevin Struhl,W. Scott Moye-Rowley,Brendan P. Cormack,Gerhard Wagner,Anders M. Näär +14 more
TL;DR: Detailed mechanistic understanding of a fungal nuclear receptor-like gene regulatory pathway provides novel therapeutic targets for the treatment of multidrug-resistant fungal infections.
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A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata.
TL;DR: Genetic analysis shows that the C. glabrata YPS genes are required for cell wall integrity, adherence to mammalian cells, survival in macrophages and virulence, and Yps proteases play an important role in cell wall re-modeling by removal and release of glycosylphosphatidylinositol-anchored cell wall proteins.
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Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing
Alejandro De Las Peñas,Shih Jung Pan,Irene Castaño,Jonathan K. Alder,Robert Cregg,Brendan P. Cormack +5 more
TL;DR: The identification and analysis of the EPA gene family provides a compelling example in an ascomycete of chromatin-based silencing of natural subtelomeric genes and provides for the first time in a pathogen, molecular insight into the transcriptionalsilencing of large subtelomersic gene families.
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Karyotype engineering by chromosome fusion leads to reproductive isolation in yeast
TL;DR: Overall, budding yeast tolerates a reduction in chromosome number unexpectedly well, providing a striking example of the robustness of genomes to change.