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Breno S. Diniz
Researcher at Centre for Addiction and Mental Health
Publications - 183
Citations - 8331
Breno S. Diniz is an academic researcher from Centre for Addiction and Mental Health. The author has contributed to research in topics: Dementia & Late life depression. The author has an hindex of 47, co-authored 163 publications receiving 6688 citations. Previous affiliations of Breno S. Diniz include Universidade Federal de Minas Gerais & University of Texas at Austin.
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Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies
TL;DR: Late-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease, and the present results suggest that it will be valuable to design clinical trials to investigate the effect of late- life depression prevention on risk of dementia.
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Inflammatory Response in the CNS: Friend or Foe?
TL;DR: Altered mutual regulation of p53 protein, a major tumor suppressor, and NF-κB, the major regulator of inflammation, seems to be crucial for the shift from beneficial to detrimental effects of neuroinflammatory reactions in neurodegeneration.
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The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review
Marta Sochocka,Katarzyna Donskow-Łysoniewska,Breno S. Diniz,Donata Kurpas,Ewa Brzozowska,Jerzy Leszek +5 more
TL;DR: The inflammatory-infectious hypothesis of AD, with the great role of the gut microbiome, starts to gently push into the shadow the amyloid cascade hypothesis that has dominated for decades.
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Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
Orestes Vicente Forlenza,Breno S. Diniz,Marcia Radanovic,Franklin Santana Santos,Leda Leme Talib,Wagner F. Gattaz +5 more
TL;DR: The notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease is supported.
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Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders.
TL;DR: The neurobiological properties of lithium are revisited in light of the available evidence of its neurotrophic and neuroprotective properties, and the rationale for its use in the treatment and prevention of neurodegenerative diseases is discussed.