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Brent A. Reynolds
Researcher at University of Florida
Publications - 154
Citations - 25152
Brent A. Reynolds is an academic researcher from University of Florida. The author has contributed to research in topics: Neural stem cell & Neurosphere. The author has an hindex of 53, co-authored 151 publications receiving 24091 citations. Previous affiliations of Brent A. Reynolds include University of Queensland & McKnight Brain Institute.
Papers
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Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
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A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes.
TL;DR: It is suggested that EGF and/or TGF alpha may act on a multipotent progenitor cell in the striatum to generate both neurons and astrocytes.
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Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo
Christopher R. R. Bjornson,Rodney L. Rietze,Brent A. Reynolds,M. Cristina Magli,Angelo L. Vescovi +4 more
TL;DR: After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells, indicating that neuralstem cells appear to have a wider differentiation potential than previously thought.
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Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells
Cindi M. Morshead,Brent A. Reynolds,Constance Craig,Michael W. McBurney,William A. Staines,Dante J. Morassutti,Samuel Weiss,Derek van der Kooy +7 more
TL;DR: In vitro formation of clonally derived spheres of cells that exhibit stem cell properties such as self-maintenance and the generation of a large number of progeny comprising the major cell types found in the central nervous system suggest that a relatively quiescent subependymal cell is the in vivo source of neural stem cells.
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Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: This study describes the first demonstration, through clonal and population analyses in vitro, of a mammalian CNS stem cell that proliferates in response to an identified growth factor (EGF) and produces the three principal cell types of the CNS.