Michael W. McBurney

TL;DR: It is shown that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes.

TL;DR: In vitro formation of clonally derived spheres of cells that exhibit stem cell properties such as self-maintenance and the generation of a large number of progeny comprising the major cell types found in the central nervous system suggest that a relatively quiescent subependymal cell is the in vivo source of neural stem cells.

TL;DR: It is shown that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors, and how down-regulating these two classes of damage-responsive mammalian factors may favor long lifespan under certain environmental conditions, such as calorie restriction is speculated.

TL;DR: No evidence for retinoic acid toxicity is found, suggesting that the effect of the drug was to induce the development of neurons and glia rather than to select against cells differentiating along other developmental pathways.

TL;DR: It is reported here that the P19 line of embryonic carcinoma cells may provide an analogous system in which drugs can be used to manipulate the formation of tissues which normally comprise the fetus, and aggregates of these same cells develop into neuronal and glial tissues but not muscle.