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Bret B. Friday
Researcher at Emory University
Publications - 4
Citations - 857
Bret B. Friday is an academic researcher from Emory University. The author has contributed to research in topics: Skeletal muscle & Myocyte. The author has an hindex of 4, co-authored 4 publications receiving 829 citations.
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Journal ArticleDOI
Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway.
Valerie Horsley,Bret B. Friday,Sarah Matteson,Kristy M. Kegley,Jonathan Gephart,Grace K. Pavlath +5 more
TL;DR: It is demonstrated that during growth of multinucleated muscle cells, myoblasts initially fuse to form myotubes with a limited number of nuclei and that subsequent nuclear addition and increases in myotube size are controlled by a molecular pathway regulated by NFATC2.
Journal ArticleDOI
Calcineurin activity is required for the initiation of skeletal muscle differentiation.
TL;DR: It is concluded that commitment of skeletal muscle cells to differentiation is calcium and calcineurin-dependent, but NFAT-independent, suggesting that multiple calcium-dependent pathways are required for differentiation.
Journal ArticleDOI
Activation and Cellular Localization of the Cyclosporine A-sensitive Transcription Factor NF-AT in Skeletal Muscle Cells
TL;DR: It is demonstrated that skeletal muscle cells express functionally active NF-AT proteins and that the nuclear translocation of individual NF- AT isoforms, which is essential for the ability to coordinate gene expression, is influenced markedly by the differentiation state of the muscle cell.
Journal ArticleDOI
Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD
TL;DR: It is demonstrated that calcineurin regulates skeletal muscle differentiation by activating MEF2 and MyoD transcription factors leading to the induction of myogenin expression.